Results 201 to 210 of about 1,379,565 (255)

GATAD2B regulates spindle assembly by affecting protein deacetylation during oocyte meiotic maturation. [PDF]

Anim Biosci
Xu Q, Yu L, Lin Y, Guo A, Zhang Y, Zhang Z, Yan G, Sun H, Cao G.   +8 more
europepmc   +1 more source

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller, Romy Busch, Giuseppe Faudone, Felia C. Haffelder, Jan Vietor, Arthur Kardanov, Úrsula López‐García, Arne Hackspacher, Georg Höfner, Vasily Morozov, Susanne F. Koch, Julian A. Marschner, Daniel Merk   +12 more
wiley   +1 more source

C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly. [PDF]

Nat Commun
Pfister JA, Agostini L, Bournonville L, Perrier A, Sankaralingam P, Bell ZG, Hamel V, Guichard P, Biertümpfel C, Mizuno N, O'Connell KF.   +10 more
europepmc   +1 more source

Systems‐level phosphoproteomics reveals calcium/calmodulin‐dependent protein kinase kinase 2‐driven kinase signaling underlying malignant phenotypes in gastric cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
CAMKK2 inhibition induces extensive phosphoproteomic remodeling associated with cell cycle regulation, RNA processing, and kinase signaling networks in gastric cancer. Integrated systems‐level analyses identified dysregulated CDK, SRPK, MAPK, and AKT signaling pathways underlying malignant phenotypes and highlighted CAMKK2 as a potential therapeutic ...
Mohd. Altaf Najar, T. S. Keshava Prasad, Prashant Kumar Modi   +2 more
wiley   +1 more source

AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation. [PDF]

Life Sci Alliance
Blengini CS, Tang S, Mendola RJ, Garrisi GJ, Swain JE, Schindler K.   +5 more
europepmc   +1 more source

Cell Surface Markers Identify Astrocyte Subpopulations in the Adult Hippocampus With a Heterogeneous Response to Aging

Glia, Volume 74, Issue 11, November 2026.
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo, Marife Cano‐Jaimez, Raquel Anta, Alba Ripollés‐Boix, Fabián Robledo‐Yagüe, Sheila Zúñiga‐Trejos, Helena Mira   +6 more
wiley   +1 more source

The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly. [PDF]

J Biol Chem
Turi da Fonte Dias AR, Hoffmann I.
europepmc   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, Volume 82, Issue 11, Page 10841-10854, November 2026.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

MoMad2 With a Conserved Function in the Spindle Assembly Checkpoint Is Required for Maintaining Appressorial Turgor Pressure and Pathogenicity of Rice Blast Fungus. [PDF]

Mol Plant Pathol
Shen T, Chen Q, Leontiou I, Wang R, Su M, Luo Q, Lu G, Wang Z, Li Y, Hardwick KG, Wang M.   +10 more
europepmc   +1 more source

Micronuclei and Other Nuclear Abnormalities in Patella Limpet as Biomarkers of Cytogenotoxicity in Recreational Port Waters

Environmental Toxicology, Volume 41, Issue 11, Page 1125-1138, November 2026.
ABSTRACT Over the past decades, the growth in human population and economic activities has led to an increase in maritime traffic. This rise puts additional pressure on marine environments, vessel fuel spills being considered to have a major impact on the ecosystem.
Carlos Valiente‐Diaz, Eva Garcia‐Vazquez, Verónica Soto‐López   +2 more
wiley   +1 more source