Results 181 to 190 of about 51,274 (213)
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The spindle: a dynamic assembly of microtubules and motors
Nature Cell Biology, 2001In all eukaryotes, a microtubule-based structure known as the spindle is responsible for accurate chromosome segregation during cell division. Spindle assembly and function require localized regulation of microtubule dynamics and the activity of a variety of microtubule-based motor proteins.
T, Wittmann, A, Hyman, A, Desai
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Spindle-Assembly Checkpoint and Gastrointestinal Cancer
New England Journal of Medicine, 2011To the Editor: Rio Frio et al. (Dec. 30 issue)1 report on a germline homozygous mutation in the spindle-assembly checkpoint gene BUB1B in a patient with a nonclassic form of the mosaic variegated aneuploidy syndrome, resulting in reduced expression, increased levels of constitutive aneuploidy, and multiple gastrointestinal neoplasms starting at 34 ...
de Voer, R.M. +3 more
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The actin cytoskeleton in spindle assembly and positioning
Trends in Cell Biology, 2009The most dramatic changes in eukaryotic cytoskeletal organization and dynamics occur during passage through mitosis. Although both spindle self-organization and actin-dependent cytokinesis have long been the subject of intense investigation, it has only recently become apparent that the actin cortex also has a key role during early mitosis.
Patricia, Kunda, Buzz, Baum
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Spatial gradients controlling spindle assembly
Biochemical Society Transactions, 2015The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran ...
Lesley N, Weaver, Claire E, Walczak
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Cdh1 is an antagonist of the spindle assembly checkpoint
Cellular Signalling, 2014The spindle assembly checkpoint (SAC) monitors unsatisfied connections of microtubules to kinetochores and prevents anaphase onset by inhibition of the ubiquitin ligase E3 anaphase-promoting complex or cyclosome (APC/C) in association with the activator Cdc20.
Masayoshi, Nagai, Takashi, Ushimaru
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Mechanisms of Mitotic Spindle Assembly and Function
2008The mitotic spindle is the macromolecular machine that segregates chromosomes to two daughter cells during mitosis. The major structural elements of the spindle are microtubule polymers, whose intrinsic polarity and dynamic properties are critical for bipolar spindle organization and function.
Claire E, Walczak, Rebecca, Heald
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The spindle assembly checkpoint in budding yeast
1997Publisher Summary This chapter discusses the spindle assembly checkpoint in budding yeast. As cells proceed through cycles of growth and division they are often challenged by environmental insult and injury as well as spontaneous errors in cellular processes. The response to cell damage requires that cells sense the damage, arrest the cell cycle, and
A F, Straight, A W, Murray
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Slipping past the spindle assembly checkpoint
Nature Cell Biology, 2013Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.
Radhika, Subramanian, Tarun M, Kapoor
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Spindle Assembly on Immobilized Chromatin Micropatterns
2014We describe a method to assemble meiotic spindles on immobilized micropatterns of chromatin built on a first layer of biotinylated BSA deposited by microcontact printing. Such chromatin patterns routinely produce bipolar spindles with a yield of 60%, and offer the possibility to follow spindle assembly dynamics, from the onset of nucleation to the ...
Céline, Pugieux +3 more
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Mitosis: Spindle assembly and chromosome motion
Current Opinion in Cell Biology, 1993New studies on mitosis demonstrate the complexity of interactions that contribute to chromosome motion and spindle assembly. Genetic and immunological approaches reveal the requirement for kinesin-related proteins during cell division in diverse cells.
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