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Spindle Assembly and Mitosis in Plants
Annual Review of Plant Biology, 2022In contrast to well-studied fungal and animal cells, plant cells assemble bipolar spindles that exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing centers like the centrosome. While plants employ some evolutionarily conserved proteins to regulate spindle morphogenesis and remodeling, many essential spindle
Bo Liu, Yuh-Ru Julie Lee
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Mechanisms underlying spindle assembly and robustness
Nature Reviews Molecular Cell Biology, 2023 The microtubule-based spindle orchestrates chromosome segregation during cell division. Following more than a century of study, many components and pathways contributing to spindle assembly have been described, but how the spindle robustly assembles remains incompletely understood.
Venecia A Valdez +2 more
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Spindle assembly checkpoint: the third decade [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 The spindle assembly checkpoint controls cell cycle progression during mitosis, synchronizing it with the attachment of chromosomes to spindle microtubules. After the discovery of themitotic arrest deficient(MAD) andbudding uninhibited by benzymidazole(BUB) genes as crucial checkpoint components in 1991, the second decade of checkpoint studies (2001 ...
Andrea Musacchio
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The Spindle Assembly and Spindle Position Checkpoints
Annual Review of Genetics, 2003▪ Abstract The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint.
Daniel J, Lew, Daniel J, Burke
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The spindle assembly checkpoint
Current Opinion in Cell Biology, 1996The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis.
A D, Rudner, A W, Murray
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Current Opinion in Cell Biology, 1997
Recent studies have revealed that, in some systems, chromatin has the ability to stabilize microtubules and organize them into bipolar spindles independently of kinetochores and centrosomes. In addition, several molecules have been identified recently that are necessary for spindle assembly; these include proteins that regulate microtubule dynamics ...
J C, Waters, E, Salmon
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Recent studies have revealed that, in some systems, chromatin has the ability to stabilize microtubules and organize them into bipolar spindles independently of kinetochores and centrosomes. In addition, several molecules have been identified recently that are necessary for spindle assembly; these include proteins that regulate microtubule dynamics ...
J C, Waters, E, Salmon
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Mitotic Spindle Assembly In Vitro
Current Protocols in Cell Biology, 2001AbstractThe protocols in this unit describe the preparation of materials for an in vitro assay of mitotic spindle assembly in Xenopus egg extracts. Fluorochrome‐labeled tubulin is used to visualize microtubule asters and spindles.
J, Merlie, R, Heald
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Spindle Assembly in Animal Cells
Annual Review of Biochemistry, 2000▪ Abstract Chromosome segregation during mitosis and meiosis is driven by a complex superstructure called the spindle. Microtubules are the primary structural component of spindles, and spindle assembly and function are intimately linked to the intrinsic dynamics of microtubules. This review summarizes spindle structure and highlights recent findings
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Chromosomes take the lead in spindle assembly
Trends in Cell Biology, 1995Several kinesin-like motor proteins have recently been found associated with chromosome arms. They seem to be involved in the so-called 'polar ejection forces' that contribute to the congression of chromosomes on the metaphase plate, and at least one of them is essential for the maintenance of spindle bipolarity.
I, Vernos, E, Karsenti
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Centrosomes in mitotic spindle assembly and orientation
Current Opinion in Structural Biology, 2021The centrosome is present in most animal cells and functions as the major microtubule-organizing center to ensure faithful chromosome segregation during cell division. As cells transition from interphase to mitosis, the duplicated centrosomes separate and move to opposite sides of the cell where the spindle assembles.
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