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Current Opinion in Cell Biology, 1997
Recent studies have revealed that, in some systems, chromatin has the ability to stabilize microtubules and organize them into bipolar spindles independently of kinetochores and centrosomes. In addition, several molecules have been identified recently that are necessary for spindle assembly; these include proteins that regulate microtubule dynamics ...
J C, Waters, E, Salmon
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Recent studies have revealed that, in some systems, chromatin has the ability to stabilize microtubules and organize them into bipolar spindles independently of kinetochores and centrosomes. In addition, several molecules have been identified recently that are necessary for spindle assembly; these include proteins that regulate microtubule dynamics ...
J C, Waters, E, Salmon
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Mitotic Spindle Assembly In Vitro
Current Protocols in Cell Biology, 2001AbstractThe protocols in this unit describe the preparation of materials for an in vitro assay of mitotic spindle assembly in Xenopus egg extracts. Fluorochrome‐labeled tubulin is used to visualize microtubule asters and spindles.
J, Merlie, R, Heald
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Spindle Assembly in Animal Cells
Annual Review of Biochemistry, 2000▪ Abstract Chromosome segregation during mitosis and meiosis is driven by a complex superstructure called the spindle. Microtubules are the primary structural component of spindles, and spindle assembly and function are intimately linked to the intrinsic dynamics of microtubules. This review summarizes spindle structure and highlights recent findings
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The spindle-assembly checkpoint in space and time
Nature Reviews Molecular Cell Biology, 2007In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint
Andrea Musacchio +2 more
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Chromosomes take the lead in spindle assembly
Trends in Cell Biology, 1995Several kinesin-like motor proteins have recently been found associated with chromosome arms. They seem to be involved in the so-called 'polar ejection forces' that contribute to the congression of chromosomes on the metaphase plate, and at least one of them is essential for the maintenance of spindle bipolarity.
I, Vernos, E, Karsenti
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Centrosomes in mitotic spindle assembly and orientation
Current Opinion in Structural Biology, 2021The centrosome is present in most animal cells and functions as the major microtubule-organizing center to ensure faithful chromosome segregation during cell division. As cells transition from interphase to mitosis, the duplicated centrosomes separate and move to opposite sides of the cell where the spindle assembles.
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The spindle: a dynamic assembly of microtubules and motors
Nature Cell Biology, 2001In all eukaryotes, a microtubule-based structure known as the spindle is responsible for accurate chromosome segregation during cell division. Spindle assembly and function require localized regulation of microtubule dynamics and the activity of a variety of microtubule-based motor proteins.
T, Wittmann, A, Hyman, A, Desai
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Cdh1 is an antagonist of the spindle assembly checkpoint
Cellular Signalling, 2014The spindle assembly checkpoint (SAC) monitors unsatisfied connections of microtubules to kinetochores and prevents anaphase onset by inhibition of the ubiquitin ligase E3 anaphase-promoting complex or cyclosome (APC/C) in association with the activator Cdc20.
Masayoshi, Nagai, Takashi, Ushimaru
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Spindle-Assembly Checkpoint and Gastrointestinal Cancer
New England Journal of Medicine, 2011To the Editor: Rio Frio et al. (Dec. 30 issue)1 report on a germline homozygous mutation in the spindle-assembly checkpoint gene BUB1B in a patient with a nonclassic form of the mosaic variegated aneuploidy syndrome, resulting in reduced expression, increased levels of constitutive aneuploidy, and multiple gastrointestinal neoplasms starting at 34 ...
de Voer, R.M. +3 more
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The actin cytoskeleton in spindle assembly and positioning
Trends in Cell Biology, 2009The most dramatic changes in eukaryotic cytoskeletal organization and dynamics occur during passage through mitosis. Although both spindle self-organization and actin-dependent cytokinesis have long been the subject of intense investigation, it has only recently become apparent that the actin cortex also has a key role during early mitosis.
Patricia, Kunda, Buzz, Baum
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