Spindle Checkpoint Regulators in Insulin Signaling [PDF]
Frontiers in Cell and Developmental Biology, 2018 The spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes.
Eunhee Choi, Hongtao Yu
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A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling [PDF]
eLife, 2017 The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation.
Zhejian Ji +4 more
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Monitoring spindle orientation: Spindle position checkpoint in charge [PDF]
Cell Division, 2010 Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation.
Pereira Gislene +2 more
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Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage. [PDF]
PLoS Genetics, 2023 To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments.
Anne MacKenzie +2 more
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Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint. [PDF]
J Cell Biol, 2020 Jackman and colleagues show that Cyclin B1-Cdk1, the major mitotic kinase, binds to the spindle checkpoint protein MAD1 and synergizes with MPS1 to facilitate MAD1 release from the nuclear pore complex and recruitment to kinetochores before nuclear ...
Jackman M +7 more
europepmc +2 more sources
Signalling dynamics in the spindle checkpoint response [PDF]
Nature Reviews Molecular Cell Biology, 2014 Susan Biggins
exaly +3 more sources
CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization. [PDF]
J Cell Biol, 2019 Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by ...
Hayward D +9 more
europepmc +2 more sources
MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling. [PDF]
J Cell Biol, 2019 Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through phosphorylation of the checkpoint kinase MPS1 and other spindle ...
Alfonso-Pérez T +4 more
europepmc +2 more sources
The ESCRT protein Chmp4c regulates mitotic spindle checkpoint signaling. [PDF]
J Cell Biol, 2018 The mitotic spindle checkpoint delays anaphase onset in the presence of unattached kinetochores, and efficient checkpoint signaling requires kinetochore localization of the Rod–ZW10–Zwilch (RZZ) complex. In the present study, we show that human Chmp4c, a
Petsalaki E, Dandoulaki M, Zachos G.
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Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing. [PDF]
Nat Commun, 2017 The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-Mad2), bound to Cdc20.
Brulotte ML +8 more
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