Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage. [PDF]
PLoS Genet, 2023 To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments.
MacKenzie A, Vicory V, Lacefield S.
europepmc +2 more sources
Spindle Checkpoint Regulators in Insulin Signaling. [PDF]
Front Cell Dev Biol, 2018 The spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes.
Choi E, Yu H.
europepmc +2 more sources
CHMP4C: A novel regulator of the mitotic spindle checkpoint. [PDF]
Mol Cell Oncol, 2018 The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport
Petsalaki E, Zachos G.
europepmc +2 more sources
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
doaj +1 more source
Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
doaj +1 more source
Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore. [PDF]
PLoS Genetics, 2014 The spindle checkpoint ensures that newly born cells receive one copy of each chromosome by preventing chromosomes from segregating until they are all correctly attached to the spindle.
Natalie J Nannas, Andrew W Murray
doaj +1 more source
Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation
Cells, 2022 Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment results in chromosome missegregation, which contributes to genome instability.
Delaney Sherwin +2 more
doaj +1 more source
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling. [PDF]
Elife, 2017 The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation.
Ji Z, Gao H, Jia L, Li B, Yu H.
europepmc +2 more sources
Bub1-mediated adaptation of the spindle checkpoint. [PDF]
PLoS Genetics, 2011 During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto +4 more
doaj +1 more source
Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae
eLife, 2021 Mitotic exit in budding yeast is dependent on correct orientation of the mitotic spindle along the cell polarity axis. When accurate positioning of the spindle fails, a surveillance mechanism named the spindle position checkpoint (SPOC) prevents cells ...
Dilara Kocakaplan +5 more
doaj +1 more source