Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation [PDF]
, 2001 Bonnie J. Howell +6 more
openalex +1 more source
HHV‐8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions
Transplant Infectious Disease, EarlyView.Risk mitigation strategies, including donors/recipients screening, DNAemia monitoring in recipients at risk, CNI‐to‐mTOR inhibitors switch, antivirals, and rituximab for KICS, may mitigate the impact of HHV‐8/KSHV infection in SOT. This review provides an update on KICS, identifies research gaps, and summarizes advances in screening and management ...
Alessandra Mularoni +9 more
wiley +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Head &Neck, Volume 48, Issue 2, Page 486-495, February 2026.ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and survival. While epidermal growth factor receptor (EGFR) is a known driver of HNSCC, EGFR inhibitors show limited efficacy as monotherapies, suggesting that effective combination therapies are needed.
Jiayu Wang +13 more
wiley +1 more source
Kinetochore Dynein Is Required for Chromosome Motion and Congression Independent of the Spindle Checkpoint [PDF]
, 2007 Zhenye Yang +3 more
openalex +1 more source
New cell lines expanding the diversity of Ewing sarcoma models
International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff +13 more
wiley +1 more source
Radiogenomics: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 2, February 2026.Radiogenomics links imaging phenotypes with genetic variations, offering potential for comprehensive understanding, cost‐effective diagnosis, and prognosis prediction to advance personalized medicine. However, its clinical application remains limited by several challenges.
Xinyu Zhang +8 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 633-648, February 2026.ABSTRACT Metamorphic proteins (MPs) can fold into two or more distinct spatial structures. Increasing interest in MPs has spurred the search for computational tools to predict proteins fold‐switching potential and model their refolding pathways. Here we address this problem by using the recently reported generative diffusion predictor UFConf, based on ...
Dmitrii A. Luzik, Nikolai R. Skrynnikov
wiley +1 more source
6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells [PDF]
, 2013 Kyung‐Sook Chung +6 more
openalex +1 more source
Characterisation and impact of intratumoural stroma in melanoma and carcinoma brain metastases
The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.Abstract Research on the tumour microenvironment in brain metastases (BM) has predominantly focused on the immune response, while the presence, morphological patterns, and potential clinical relevance of intratumoural stroma remain less intensively investigated.
Dave Bandke +6 more
wiley +1 more source