Results 171 to 180 of about 303,580 (303)

Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis

BioEssays, Volume 48, Issue 1, January 2026.
The synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Ariel L. Gold, Yumi Kim
wiley   +1 more source

Retroperitoneal Dedifferentiated Liposarcoma With Penetrating Abscess Formation Secondary to Ileal Invasion: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Liposarcoma is a relatively common malignant soft tissue tumor in adults. Dedifferentiated liposarcoma (DLS) is a particularly invasive subtype characterized by high recurrence rates and a poor prognosis. We describe a case of a retroperitoneal liposarcoma with poor differentiation that presented with peritonitis accompanied by ileal ...
Kenichiro Yambe, Kei Nakagawa, Kuniharu Yamamoto, Hiroto Sakurai, Kazuhiro Takami, Noriko Kondo, Chikashi Shibata, Yu Katayose   +7 more
wiley   +1 more source

Delayed Aggressive Local Recurrence of Chondroblastic Osteosarcoma 3 Years After an Excellent Pathological Response: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Late recurrence of osteosarcoma after a prolonged disease‐free interval is an uncommon but significant clinical challenge, representing a failure of primary therapy to eradicate microscopic residual disease. We present the case of a 19‐year‐old male diagnosed with chondroblastic osteosarcoma of the proximal tibia who was treated with standard ...
Abdul Hannan, Bilal Aslam, Natasha Hastings, Deepa Lachhman Das, Zahra Sania, Marium Mansoor, Fazeela Bibi, Khalil El Abdi, Samreen Najeeb, Kristen Batten, Manisha Kumari, Said Hamid Sadat   +11 more
wiley   +1 more source

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint [PDF]

, 2020
Yael Cohen‐Sharir, James M. McFarland, Mai Abdusamad, Carolyn Marquis, Helen Tang, Marica Rosaria Ippolito, Sara V. Bernhard, Kathrin Laue, Heidi L.H. Malaby, Andrew Jones, Mariya Kazachkova, Nicholas Lyons, Ankur K. Nagaraja, Adam J. Bass, Rameen Beroukhim, Stefano Santaguida, Jason Stumpff, Todd R. Golub, Zuzana Štorchová, Uri Ben‐David   +19 more
openalex   +1 more source

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
wiley   +1 more source

A new view of the spindle checkpoint [PDF]

, 2001
M. Andrew Hoyt
openalex   +1 more source

PIGN Spatiotemporally Regulates the Spindle Assembly Checkpoint Proteins in Myelodysplastic Syndromes [PDF]

, 2020
Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong‐Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu   +9 more
openalex   +1 more source

Multi‐omics analysis identifies PUS7 as an immune modulator driving NETs‐mediated macrophage polarization in pancreatic cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
PUS7 reshapes the PDAC immune landscape primarily by inducing NETs, which drive macrophage polarization from M1 to M2, fostering immune suppression and tumour progression. The inhibitory effects of S428‐1145 and DNase I on pancreatic cancer are mediated through blocking the PUS7/NETs/M2 macrophage pathway.
Jike Fang, Shiye Ruan, Yajie Wang, Yue Chen, Fuxin Huang, Zhongyan Zhang, Chuanzhao Zhang, Baohua Hou, Shanzhou Huang   +8 more
wiley   +1 more source

The spindle checkpoint protein MAD1 regulates the expression of E-cadherin and prevents cell migration

, 2011
Yue-Li Juang
openalex   +2 more sources

Accumulation of Mad2–Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae [PDF]

, 2006
Luigi Nezi, Giulia Rancati, Anna De Antoni, Sebastiano Pasqualato, Simonetta Piatti, Arianna Esposito Verza   +5 more
openalex   +1 more source