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The kinetochore and spindle checkpoint in mammals
Frontiers in Bioscience, 2008The two daughter cells that result from each and every cell division receive an identical set of chromosomes. This is accomplished by pulling each copy of a pair of duplicated sister chromatids to opposite poles during mitosis. Inaccuracies in this process lead to aneuploidy, which is a major cause of birth defects and can facilitate the rise of ...
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The spindle checkpoint in Xenopus Laevis
Frontiers in Bioscience, 2008The spindle checkpoint ensures accurate chromosome segregation by delaying anaphase onset until all kinetochores have properly established bipolar attachment to spindle microtubules. This mechanism is important for all eukaryotic cells and is evolutionarily conserved.
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The Spindle Checkpoint in the Dinoflagellate Crypthecodinium cohnii
Experimental Cell Research, 2000Dinoflagellates are a major group of organisms with an extranuclear spindle. As the purpose of the spindle checkpoint is to ensure proper alignment of the chromosomes on the spindle, dinoflagellate cell cycle control may be compromised to accomodate the extranuclear spindle. In the present study, we demonstrated that nocodazole reversibly prolonged the
Yeung, Patrick Ka Kit +5 more
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The spindle checkpoint: tension versus attachment
Trends in Cell Biology, 2005The spindle checkpoint ensures the fidelity of chromosome segregation by preventing cell-cycle progression until all the chromosomes make proper bipolar attachments to the mitotic spindle and come under tension. Despite significant advances in our understanding of spindle checkpoint function, the primary signal that activates the spindle checkpoint ...
Benjamin A. Pinsky, Sue Biggins
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The spindle assembly checkpoint in budding yeast
1997Publisher Summary This chapter discusses the spindle assembly checkpoint in budding yeast. As cells proceed through cycles of growth and division they are often challenged by environmental insult and injury as well as spontaneous errors in cellular processes. The response to cell damage requires that cells sense the damage, arrest the cell cycle, and
Aaron F. Straight, Andrew W. Murray
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The kinetochore and spindle checkpoint in vertebrate cells
Frontiers in Bioscience, 2008The centromere is a specialized region of eukaryotic chromosomes that is essential for faithful chromosome segregation during mitosis and meiosis. A kinetochore is assembled at the centromere of each chromatid of a replicated chromosome and forms a dynamic interface with microtubules of the mitotic spindle.
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Spindle positioning and its impact on vertebrate tissue architecture and cell fate
Nature Reviews Molecular Cell Biology, 2021Marina Mapelli +2 more
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