Results 261 to 270 of about 303,580 (303)
Some of the next articles are maybe not open access.
Flies without a spindle checkpoint
Nature Cell Biology, 2007Mad2 has a key role in the spindle-assembly checkpoint (SAC) - the mechanism delaying anaphase onset until all chromosomes correctly attach to the spindle. Here, we show that unlike every other reported case of SAC inactivation in metazoans, mad2-null Drosophila are viable and fertile, and their cells almost always divide correctly despite having no ...
Eulalie, Buffin +2 more
openaire +2 more sources
The spindle checkpoint: tension versus attachment
Trends in Cell Biology, 2005The spindle checkpoint ensures the fidelity of chromosome segregation by preventing cell-cycle progression until all the chromosomes make proper bipolar attachments to the mitotic spindle and come under tension. Despite significant advances in our understanding of spindle checkpoint function, the primary signal that activates the spindle checkpoint ...
Benjamin A, Pinsky, Sue, Biggins
openaire +2 more sources
Spindle-Assembly Checkpoint and Gastrointestinal Cancer
New England Journal of Medicine, 2011To the Editor: Rio Frio et al. (Dec. 30 issue)1 report on a germline homozygous mutation in the spindle-assembly checkpoint gene BUB1B in a patient with a nonclassic form of the mosaic variegated aneuploidy syndrome, resulting in reduced expression, increased levels of constitutive aneuploidy, and multiple gastrointestinal neoplasms starting at 34 ...
de Voer, R.M. +3 more
openaire +2 more sources
Complexity in the spindle checkpoint
Current Opinion in Genetics & Development, 2000Cell viability requires accurate chromosome segregation at mitosis. The spindle checkpoint ensures that anaphase is not attempted until the sister chromatids of each chromosome are attached to spindle microtubules from opposite poles. The checkpoint mechanism involves a signal transduction cascade that is more complex than was originally envisioned.
openaire +2 more sources
The Spindle Checkpoint: Assays for the Analysis of Spindle Checkpoint Arrest and Recovery
2009The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation by inhibiting anaphase onset until all chromosomes have established stable bipolar attachments. Here we describe a number of protocols that can be used to assay the ability of budding and fission yeast cells to (1) establish and maintain a spindle ...
Josefin, Fernius, Kevin G, Hardwick
openaire +2 more sources
Anaphase Inactivation of the Spindle Checkpoint
Science, 2006The spindle checkpoint delays cell cycle progression until microtubules attach each pair of sister chromosomes to opposite poles of the mitotic spindle. Following sister chromatid separation, however, the checkpoint ignores chromosomes whose kinetochores are attached to only one spindle pole, a state that activates the checkpoint prior to metaphase. We
William J, Palframan +4 more
openaire +2 more sources
The Spindle Checkpoint and Chromosomal Stability
2006Normal human somatic cells contain 46 chromosomes (22 pairs of autosomes and two sex chromosomes). Chromosome missegregation leads to abnormal numbers of chromosomes or aneuploidy. This form of genetic instability alters the dosages of large subsets of genes, which can result in severe disease phenotypes. Most human cancer cells are aneuploid.
W, Qi, H, Yu
openaire +2 more sources
A p53-Dependent Mouse Spindle Checkpoint
Science, 1995Cell cycle checkpoints enhance genetic fidelity by causing arrest at specific stages of the cell cycle when previous events have not been completed. The tumor suppressor p53 has been implicated in a G1 checkpoint. To investigate whether p53 also participates in a mitotic checkpoint, cultured fibroblasts from p53-deficient mouse embryos were exposed to ...
S M, Cross +7 more
openaire +2 more sources
Slipping past the spindle assembly checkpoint
Nature Cell Biology, 2013Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.
Radhika, Subramanian, Tarun M, Kapoor
openaire +2 more sources
The spindle checkpoint in Xenopus Laevis
Frontiers in Bioscience, 2008The spindle checkpoint ensures accurate chromosome segregation by delaying anaphase onset until all kinetochores have properly established bipolar attachment to spindle microtubules. This mechanism is important for all eukaryotic cells and is evolutionarily conserved.
openaire +2 more sources