Results 31 to 40 of about 303,580 (303)

Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore. [PDF]

PLoS Genetics, 2014
The spindle checkpoint ensures that newly born cells receive one copy of each chromosome by preventing chromosomes from segregating until they are all correctly attached to the spindle.
Natalie J Nannas, Andrew W Murray
doaj   +1 more source

Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation

Cells, 2022
Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment results in chromosome missegregation, which contributes to genome instability.
Delaney Sherwin, Abigail Huetteman, Yanchang Wang   +2 more
doaj   +1 more source

Bub1-mediated adaptation of the spindle checkpoint. [PDF]

PLoS Genetics, 2011
During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto, Ashutosh Mishra, Rashid Abdulle, Clive A Slaughter, Katsumi Kitagawa   +4 more
doaj   +1 more source

The synaptonemal complex protein Zip1 promotes bi-orientation of centromeres at meiosis I. [PDF]

PLoS Genetics, 2009
In meiosis I, homologous chromosomes become paired and then separate from one another to opposite poles of the spindle. In humans, errors in this process are a leading cause of birth defects, mental retardation, and infertility.
Mara N Gladstone, David Obeso, Hoa Chuong, Dean S Dawson   +3 more
doaj   +1 more source

Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae

eLife, 2021
Mitotic exit in budding yeast is dependent on correct orientation of the mitotic spindle along the cell polarity axis. When accurate positioning of the spindle fails, a surveillance mechanism named the spindle position checkpoint (SPOC) prevents cells ...
Dilara Kocakaplan, Hüseyin Karabürk, Cansu Dilege, Idil Kirdök, Seyma Nur Bektas, Ayse Koca Caydasi   +5 more
doaj   +1 more source

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Haematologica, 2013
Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch, Andrea Schmidts, Marie Follo, Josefina Udi, Julia Felthaus, Dietmar Pfeifer, Monika Engelhardt, Ralph Wäsch   +7 more
doaj   +1 more source

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Science Translational Medicine, 2020
YAP and FOXM1 are mediators of EGFR inhibitor resistance, and spindle proteins are therapeutic targets for this multidrug-resistant phenotype. Path of least resistance Drugs that inhibit the epidermal growth factor (EGFR) are used in a number of cancer ...
M. Nilsson, Huiying Sun, J. Robichaux, Matthias Pfeifer, U. McDermott, Jon Travers, L. Diao, Y. Xi, P. Tong, Li Shen, Mia Hofstad, Masanori Kawakami, X. Le, Xi Liu, Youhong Fan, A. Poteete, Limei Hu, M. Negrão, H. Tran, E. Dmitrovsky, D. Peng, D. Gibbons, Jing Wang, J. Heymach   +23 more
semanticscholar   +1 more source

Use of the Protein Ontology (PRO) for Multi-Faceted Analysis of Biological Processes: a Case Study of the Spindle Checkpoint

Frontiers in Genetics, 2013
As a member of the Open Biomedical Ontologies (OBO) foundry, the Protein Ontology (PRO) provides an ontological representation of protein forms and complexes and their relationships.
Karen E Ross, Cecilia N Arighi, Jia eRen, Darren A Natale, Hongzhan eHuang, Cathy H Wu   +5 more
doaj   +1 more source

Bub1 kinase in the regulation of mitosis

Animal Cells and Systems, 2021
Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
doaj   +1 more source

The mitotic spindle checkpoint [PDF]

Current Biology, 2001
Fantastic progress has been made in understanding the spindle checkpoint, the guardian of balanced chromosome segregation. However, several basic questions and many details remain to be worked out. In the meantime, the use of chimeric fluorescent proteins and ever better imaging technology has enhanced the stunning videos of mitosis made today ...
openaire   +2 more sources