Results 31 to 40 of about 4,116 (226)
Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control [PDF]
Comput Struct Biotechnol J. 2015 Apr 9;13:320-8, 2016 The spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anaphase onset, until all chromosomes are properly attached to the mitotic spindle. The SAC delays mitotic progression by preventing activation of the ubiquitin ligase anaphase-promoting complex (APC/C) or cyclosome; whose activation by Cdc20 is required for sister ...
arxiv +1 more source
The spindle checkpoint, aneuploidy, and cancer [PDF]
Oncogene, 2004 Cancer cells contain abnormal number of chromosomes (aneuploidy), which is a prevalent form of genetic instability in human cancers. Defects in a cell cycle surveillance mechanism called the spindle checkpoint contribute to chromosome instability and aneuploidy.
Rajnish Bharadwaj, Hongtao Yu
openaire +2 more sources
Modeling potent pathways for APC/C inhibition: pivotal roles for MCC and BubR1 [PDF]
OMICS: A Journal of Integrative Biology. May 2015, 19(5): 294-305, 2016 The highly conserved spindle assembly checkpoint (SAC) ensures that the sister chromatids of the duplicated genome are not separated and distributed to the spindle poles before all chromosomes have been properly linked to the microtubules of the mitotic spindle.
arxiv +1 more source
Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. [PDF]
PLoS Genetics, 2012 The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation.
Fengzhi Jin +4 more
doaj +1 more source
Accurate chromosome segregation by probabilistic self-organization [PDF]
BMC Biology 2015 13:65, 2014 Background: For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-orientation). Incorrect attachments of kinetochore microtubules (kMTs) lead to chromosome mis-segregation and aneuploidy, which is often
arxiv +1 more source
Oxidative Stress Overrides the Spindle Checkpoint [PDF]
Cell Cycle, 2007 Aneuploidy, an abnormal chromosome set, can ensue from failure of the spindle checkpoint, the safeguard mechanism that halts anaphase onset until mitotic spindle assembly. Inefficiency of cells to maintain the normal chromosome set across cell generations has been linked to tumorigenesis and senescence.
D'ANGIOLELLA V +2 more
openaire +4 more sources
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
doaj +1 more source
Cystathionine β‐synthase is required for oocyte quality by ensuring proper meiotic spindle assembly
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 CBS is required for oocyte quality by ensuring proper spindle assembly. During oocyte meiotic maturation, CBS ensures spindle assembly by participating in the acetylation of α‐tubulin to stabilize microtubules. Kinetochores remain attached by spindle microtubules. SAC is removed from the kinetochores and then the chromosomes can be separated correctly.
Yan Cao +9 more
wiley +1 more source
Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
doaj +1 more source
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint
Cell Division, 2007 During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit.
Yu Hongtao, Díaz-Martínez Laura A
doaj +1 more source