Measuring and modeling polymer gradients argues that spindle microtubules regulate their own nucleation [PDF]
, 2017 Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation of microtubule nucleation remain poorly understood.
arxiv +1 more source
Gap junction plasticity can lead to spindle oscillations [PDF]
arXiv, 2017 Patterns of waxing and waning oscillations, called spindles, are observed in multiple brain regions during sleep. Spindle are thought to be involved in memory consolidation. The origin of spindle oscillations is ongoing work but experimental results point towards the thalamic reticular nucleus (TRN) as a likely candidate.
arxiv
MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation
Cell Division, 2007 Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
doaj +1 more source
Journal of the Formosan Medical Association, 2009 Aneuploidy is a major manifestation of chromosomal instability, which is defined as a numerical abnormality of chromosomes in diploid cells. It is highly prevalent in a variety of human malignancies. Increased chromosomal instability is the major driving
Wei Dai
doaj +1 more source
Logspace computations for Garside groups of spindle type [PDF]
arXiv, 2013 M. Picantin introduced the notion of Garside groups of spindle type, generalizing the 3-strand braid group. We show that, for linear Garside groups of spindle type, a normal form and a solution to the conjugacy problem are logspace computable. For linear Garside groups of spindle type with homogenous presentation we compute a geodesic normal form in ...
arxiv
USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy. [PDF]
Cell Death Dis, 2023 Campos-Iglesias D +7 more
europepmc +1 more source
Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast [PDF]
arXiv, 2016 Kinesin-8 motor proteins destabilize microtubules. Their absence during cell division is associated with disorganized mitotic chromosome movements and chromosome loss. Despite recent work studying effects of kinesin 8s on microtubule dynamics, it remains unclear whether the kinesin-8 mitotic phenotypes are consequences of their effect on microtubule ...
arxiv
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation [PDF]
, 2001 Bonnie J. Howell +6 more
openalex +3 more sources
PLoS Genetics, 2016 The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C).
Judith Zich +11 more
doaj +1 more source
Fission Yeast Bub1 Is a Mitotic Centromere Protein Essential for the Spindle Checkpoint and the Preservation of Correct Ploidy through Mitosis [PDF]
, 1998 Pascal Bernard +2 more
openalex +1 more source