Results 41 to 50 of about 1,861,377 (295)
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint [PDF]
, 2007 Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins
Emma M J King +8 more
core +2 more sources
Spindle cell carcinoma of the conjunctiva: A rare entity
Indian Journal of Ophthalmology, 2016 An 85-year-old male presented with painless bulging lesion over the cornea. Clinical history, diagnostic imaging studies, and histopathologic sections were evaluated.
Muge Coban-Karatas +3 more
doaj +1 more source
Spindle Cell Metaplastic Breast Carcinoma with Leiomyoid Differentiation: A Case Report [PDF]
, 2011 Background: Metaplastic carcinoma of the breast is a rare but distinct entity within the group of undifferentiated invasive carcinomas. This entity accounts for less than 0.5% of all breast cancers and contains elements of epithelial (ductal ...
Jauch, Karl-Walter +11 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
, 2022 AN00472756_001_l. Glass spindle-whorl. All these images are © Trustees of the British Museum. These free low-resolution images are covered also under the British Museum's Terms and Conditions (http://www.britishmuseum.org/about_this_site/terms_of_use ...
Woruldhord Project Team (14251345)
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Electronics, 2022 In the research on the aerostatic spindle, for quantifying the influence of shaft shape errors on its rotation accuracy, the calculation models of unbalanced air film force (UAFF) and centrifugal inertia force (CIF) are established. Based on the typical shape of the shaft, three composite cylinder models are constructed.
Guoqing Zhang +5 more
openaire +1 more source
Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes [PDF]
, 2007 The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Rischitor, Patricia E +8 more
core +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. [PDF]
The Journal of cell biology, 1996 M-phase checkpoints inhibit cell division when mitotic spindle function is perturbed. Here we show that the Saccharomyces cerevisiae MPS1 gene product, an essential protein kinase required for spindle pole body (SPB) duplication (Winey et al., 1991; Lauze et al., 1995), is also required for M-phase check-point function.
E, Weiss, M, Winey
openaire +2 more sources