Aging Cell, Volume 25, Issue 2, February 2026.A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang +14 more
wiley +1 more source
The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapy
Frontiers in MedicineSpindle Pole Body Component 25 (SPC25), a critical component of the NDC80 kinetochore complex, plays an essential role in maintaining chromosomal stability during mitosis.
Yigang Jin +8 more
doaj +1 more source
hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif +12 more
wiley +1 more source
Protein Kinase C Regulates Meiosis in Mammalian Oocytes
BioEssays, Volume 48, Issue 1, January 2026.Protein kinase C (PKC) participates in the regulation of mammalian oocyte meiosis. PKC is involved in meiosis resumption in prophase I and in the stabilization of meiosis I and meiosis II spindles. PKC stimulates the maturation‐promoting factor during fertilization and stabilizes the mitotic spindle during early embryo development. ABSTRACT The protein
Jaroslav Kalous +2 more
wiley +1 more source
Dissociation of the nuclear basket triggers chromosome loss in aging yeast
eLifeIn many organisms, aging is a clear risk factor for chromosome missegregation, the main source of aneuploidy. Here, we report that old yeast cells lose chromosomes by partitioning them asymmetrically to their daughter cells together with the pre-existing
Mihailo Mirkovic +6 more
doaj +1 more source
Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis [PDF]
, 2006 Oren Gordon +6 more
openalex +1 more source
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts
Cytoskeleton, Volume 83, Issue 1, Page 29-39, January 2026.ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena +4 more
wiley +1 more source
p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites. [PDF]
, 1995 K Nabeshima +5 more
openalex +1 more source
Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle
Cytoskeleton, Volume 83, Issue 1, Page 40-52, January 2026.ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley +8 more
wiley +1 more source