Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells [PDF]
Frontiers in Immunology, 2022 Tumor-associated macrophages (TAMs) are involved in the growth of prostate cancer (PrC), while the molecular mechanisms underlying the interactive crosstalk between TAM and PrC cells remain largely unknown.
Feilun Cui +3 more
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Characterization of a novel interaction of the Nup159 nucleoporin with asymmetrically localized spindle pole body proteins and its link with autophagy. [PDF]
PLoS Biology, 2023 Both the spindle microtubule-organizing centers and the nuclear pore complexes (NPCs) are convoluted structures where many signaling pathways converge to coordinate key events during cell division.
Inés García de Oya +5 more
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Building a bridge to a new spindle pole body [PDF]
Journal of Cell Biology, 2015 ![Figure][1] In a wild-type cell, a satellite SPB (S) begins to assemble at the end of a bridge (B) extending from a mother SPB. [Seybold et al][2] describe how three proteins interact to form a structure that initiates the duplication of spindle pole bodies (SPBs), the yeast equivalent ...
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Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body [PDF]
Cells, 2018 The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle.
Diana Rüthnick, Elmar Schiebel
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Is cohesin required for spindle-pole-body/centrosome cohesion? [PDF]
Communicative & Integrative Biology, 2012 Centrosomes are microtubule-organizing centers that nucleate spindle microtubules during cell division. In budding yeast, the centrosome, often referred to as the spindle pole body, shares structural components with the centriole, the central core of the animal centrosome. The parental centrosome is duplicated when DNA replication takes place.
Hong-Guo Yu, Hui Jin, Martin Avey
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Lessons from yeast: the spindle pole body and the centrosome [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 The yeast spindle pole body (SPB) is the functional equivalent of the centrosome. Most SPB components have been identified and their functions partly established. This involved a large variety of techniques which are described here, and the potential use of some of these in the centrosome field is highlighted.
Kilmartin JV.
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Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha [PDF]
eLife, 2017 Cytoplasmic microtubules (cMT) control mitotic spindle positioning in many organisms, and are therefore pivotal for successful cell division. Despite its importance, the temporal control of cMT formation remains poorly understood.
Hiromi Maekawa +5 more
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Anatomy of the fungal microtubule organizing center, the spindle pole body [PDF]
Current Opinion in Structural Biology, 2021 The fungal kingdom is large and diverse, representing extremes of ecology, life cycles and morphology. At a cellular level, the diversity among fungi is particularly apparent at the spindle pole body (SPB). This nuclear envelope embedded structure, which is essential for microtubule nucleation, shows dramatically different morphologies between ...
Jaspersen SL.
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Bud14 function is crucial for Spindle Pole Body size maintenance [PDF]
Turkish Journal of BiologySpindle pole bodies (SPB), the functional equivalent of centrosomes in yeast, duplicate through generation of a new SPB next to the old one. However, SPBs are dynamic structures that can grow and exchange, and mechanisms that regulate SPB size remain largely unknown.
GİRGİN, Sevilay Münire +1 more
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The core spindle pole body scaffold Ppc89 links the pericentrin orthologue Pcp1 to the fission yeast spindle pole body via an evolutionarily conserved interface [PDF]
Molecular Biology of the CellCentrosomes and spindle pole bodies (SPBs) are important for mitotic spindle formation and serve as cellular signaling platforms. Although centrosomes and SPBs differ in morphology, many mechanistic insights into centrosome function have been gleaned from SPB studies.
Jun-Song Chen +8 more
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