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A fluid droplet harvests the force generated by shrinking microtubules in living cells
Morelli K+6 more
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Exploring the pole: an EMBO conference on centrosomes and spindle pole bodies [PDF]
The centrosome and spindle pole body community gathered for its triennial meeting from 12-16 September, 2008 at EMBL in Heidelberg (Germany).
Sue L. Jaspersen, Tim Stearns
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The spindle pole body of yeast [PDF]
Microtubule organizing centers play an essential cellular role in nucleating microtubule assembly and establishing the microtubule array. The microtubule organizing center of yeast, the spindle pole body (SPB), shares many functions and properties with those other organisms.
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Microtubule organization by the budding yeast spindle pole body
Biology of the Cell, 1999In budding yeast microtubule organizing functions are provided by the spindle pole body (SPB), a multi‐layered structure that is embedded in the nuclear envelope throughout the cell cycle. The SPB organizes the nuclear and cytoplasmic microtubules which are spatially and functionally distinct.
Knop, Michael+2 more
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Asymmetric mitotic segregation of the yeast spindle pole body
Cell, 1992The yeast KAR1 gene is required for spindle pole body (SPB) duplication and nuclear fusion. We determine here that KAR1-beta-galactosidase hybrid proteins localize to the outer face of the SPB. Remarkably, after SPB duplication, the hybrid protein was found associated with only one of the two SPBs, usually the one that enters the bud.
Tom Roberts+4 more
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Assembly and functions of the spindle pole body in budding yeast
Trends in Genetics, 1993The spindle pole body (SPB) serves as the centrosome in yeasts and in a variety of other lower eukaryotes. In Saccharomyces cerevisiae, this organelle controls the assembly of all microtubules in the cell, acting not only as a pole of the mitotic or meiotic spindle but also as the site from which cytoplasmic microtubules emanate.
Breck Byers, Mark Winey
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Spindle pole body duplication: a model for centrosome duplication?
Trends in Cell Biology, 2000The yeast spindle pole body (SPB) is the functional equivalent of the centrosome and forms the two poles of the mitotic spindle. Before mitosis, both SPBs and centrosomes are present as single copies and must be duplicated to form the bipolar spindle. SPB components have been identified using a combination of biochemistry and genetics, and their role ...
John V. Kilmartin, Ian R. Adams
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Meiosis in Coprinus: IV. morphology and behaviour of spindle pole bodies [PDF]
ABSTRACT Meiotic synchrony in the genus Coprinus has permitted the sequential study of spindle pole body (SPB) behaviour through the meiotic process. The SPBs are monoglobular in the young basidia immediately after the last premeiotic mitosis. From 10 to 15 h before karyogamy until pachytene, spindle pole bodies are not found.
B. C. Lu, N. B. Raju
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Electron Microscopy of Spindle Pole Bodies in Pathogenic Fungi
Nippon Ishinkin Gakkai Zasshi, 2010Morphology and dynamics of the spindle pole bodies (SPBs) in Exophiala dermatitidis and Cryptococcus neoformans were examined by freeze-substitution and serial ultrathin sectioning electron microscopy. The SPBs showed double forms and were located on the nuclear envelope in G1 phase, entered the nuclear membrane or the periphery of nucleus in M phase ...
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