Results 71 to 80 of about 110,511 (285)
EMBO reports, 2006 The third EMBO workshop on Centrosomes and Spindle Pole Bodies, organized by M. Bornens, S.J. Doxsey, M. Knop and J. Raff, was held at the European Molecular Biology Laboratory in Heidelberg, Germany, between 23 and 27 September 2005. ![][1] This series of meetings (Palazzo, 2002; Stearns & Winey, 1997) began as a joint ASCB/EMBO venture in 1997 ...
Hagan, Iain M., Palazzo, Robert E.
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Sid2p, a Spindle Pole Body Kinase That Regulates the Onset of Cytokinesis [PDF]
The Journal of Cell Biology, 1999 The fission yeast Schizosaccharomyces pombe divides by medial fission through the use of an actomyosin contractile ring. Precisely at the end of anaphase, the ring begins to constrict and the septum forms. Proper coordination of cell division with mitosis is crucial to ensure proper segregation of chromosomes to daughter cells.
Sparks, Cynthia A. +2 more
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Spindle pole bodies function as signal amplifiers in the Mitotic Exit Network [PDF]
Molecular Biology of the Cell, 2020 The signal transduction cascade, known as the mitotic exit network (MEN), detects nuclear position by scaffolding its GTPase onto the spindle pole body that moves into the daughter cell during anaphase. Propagating the MEN kinase cascade onto two spindle pole bodies amplifies MEN signaling, resulting in a timely exit from mitosis.
Campbell, Ian W +2 more
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Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle [PDF]
arXiv, 2022 During cell division, the spindle generates force to move chromosomes. In mammals, microtubule bundles called kinetochore-fibers (k-fibers) attach to and segregate chromosomes. To do so, k-fibers must be robustly anchored to the dynamic spindle. We previously developed microneedle manipulation to mechanically challenge k-fiber anchorage, and observed ...
arxiv
Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans. [PDF]
, 2015 Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the ...
Andaya, Armann +9 more
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Spindle Alignment Regulates the Dynamic Association of Checkpoint Proteins with Yeast Spindle Pole Bodies [PDF]
Developmental Cell, 2009 In many polarized cells, the accuracy of chromosome segregation depends on the correct positioning of the mitotic spindle. In budding yeast, the spindle positioning checkpoint (SPOC) delays mitotic exit when the anaphase spindle fails to extend toward the mother-daughter axis.
Ayse Koca Caydasi, Gislene Pereira
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An updated view on the centrosome as a cell cycle regulator
Cell Division, 2022 The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes in centrosomal structure or number have been associated with human diseases ranging from congenital ...
Muyang Lin +2 more
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Journal of Kidney Cancer and VHL, 2022 An inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with an unclear origin that can arise anywhere on the body. It contains spindle cells (myofibroblasts) with different inflammatory elements.
Ali Ariafar +4 more
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N-terminal regions of Mps1 kinase determine functional bifurcation [PDF]
Spindle pole body components Spc29 and Cdc31 are identified as targets of Mps1 kinase, which, when phosphorylated, regulate protein–protein interactions in the spindle pole ...
Adams +66 more
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Mechanisms of spindle positioning. [PDF]
, 2013 Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions that are crucial for animal development and oocyte maturation, respectively.
McNally, Francis J
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