Results 1 to 10 of about 315,999 (305)

Osteoporosis in the Spine: Recent Update in Biology, Molecular Therapy and Management

Journal of Orthopaedic Translation, 2016
doaj   +3 more sources

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

Nature Structural &Molecular Biology, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +2 more sources

The effect of synthesized cartilage tissue from human adipose-derived mesenchymal stem cells in orthopedic spine surgery in patients with osteoarthritis.

Cellular and Molecular Biology, 2021
Osteoarthritis is a joint disease that causes degeneration of articular cartilage and involvement of subcutaneous bone and inflammation of surrounding tissues. It can affect any joints, but the most common joints are the joints of the hands, feet, knees,
Weijie Tang, Xinhua Guan, Jingqi Han, XiLing Yin, Feng Zuoji   +4 more
semanticscholar   +1 more source

Placement of Unilateral Cortical Bone Trajectory Screws in Previously Instrumented Pedicle without Removal of Existing Hardware for Adjacent Segment Disease

Case Reports in Orthopedics, 2021
Adjacent segment disease (ASD) in the lumbar spine is a possible consequence in segments adjacent to a fusion. As the number of lumbar fusions in the United States increases, the rates of ASD will continue to climb.
Rojeh Melikian, Sofia Yeremian
doaj   +1 more source

Diagnosis and treatment of spine and spinal cord tumors in the era of molecular pathological diagnosis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
With the publication of the "2021 World Health Organization Classification of Tumors of the Central Nervous System (fifth edition)" (hereinafter referred to as the 2021 version of tumor classification), a new model of histological and molecular ...
JIAN Feng⁃zeng, WANG Xing⁃wen
doaj   +1 more source

Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells

Stem Cells International, 2022
The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine.
Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao   +10 more
doaj   +1 more source

Sa12b Improves Biological Activity of Human Degenerative Nucleus Pulposus Mesenchymal Stem Cells in a Severe Acid Environment by Inhibiting Acid-Sensitive Ion Channels

Frontiers in Bioengineering and Biotechnology, 2022
Sa12b is a wasp peptide that can inhibit acid-sensitive ion channels (ASICs). The biological effects of nucleus pulposus mesenchymal stem cells (NP-MSCs) have not been investigated. Therefore, this study investigated the effect of Sa12b on the biological
Ziyu Wang, Letian Han, Haoyu Chen, Shengquan Zhang, Sumei Zhang, Hua Zhang, Yuhao Li, Hui Tao, Jie Li   +8 more
doaj   +1 more source

Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation

Cell Regeneration, 2022
Long non-coding (lnc) RNA plays important roles in many cellular processes. The function of the vast majority of lncRNAs remains unknown. Here we identified that lncRNA-1700113A16RIK existed in skeletal muscle stem cells (MuSCs) and was significantly ...
Xin Fu, Sheng Li, Minzhi Jia, Bo Xu, Lele Yang, Ruimiao Ma, Hong Cheng, Wenjun Yang, Ping Hu   +8 more
doaj   +1 more source

A Dynamic Model of Interactions of Ca^(2+), Calmodulin, and Catalytic Subunits of Ca^(2+)/Calmodulin-Dependent Protein Kinase II [PDF]

, 2010
During the acquisition of memories, influx of Ca^(2+) into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses.
A Hoelz, A Muller, A Persechini, AJ Silva, AJ Silva, B Shapiro, BB Olwin, BB Olwin, BE Finn, BE Finn, DM Santucci, DM Watterson, DX Keller, GD Wyss, GJ Augustine, J Lisman, J Rose, JC Helton, JM Bradshaw, JM Shifman, K Shen, KM Franks, M Maravall, Mary B. Kennedy, MB Kennedy, MB Kennedy, MB Kennedy, MI Stefan, MK Bennett, NE Erondu, OS Rosenberg, P De Koninck, PI Hanson, PJ Sjostrom, R Chattopadhyaya, R Phillips, Rama Ranganathan, RC Malenka, RE Kerr, RJ Colbran, RL Iman, S Kakiuchi, S Linse, S Marino, S Mirzoeva, SE Brown, SG Miller, Shirley Pepke, SM Blower, SR Martin, Stefan Mihalas, T Meyer, Tamara Kinzer-Ursem, TH Crouch, TL Kinzer-Ursem, TR Gaertner, WE Meador, Y Kubota, Y Ouyang, YS Babu, Z Xia   +60 more
core   +7 more sources

Single-cell transcriptomics reveals ependymal subtypes related to cytoskeleton dynamics as the core driver of syringomyelia pathological development

iScience, 2023
Summary: Syringomyelia is a common clinical lesion associated with cerebrospinal fluid flow abnormalities. By a reversible model with chronic extradural compression to mimic human canalicular syringomyelia, we explored the spatiotemporal pathological ...
Chunli Lu, Xianming Wu, Xinyu Wang, Zhifeng Xiao, Longbing Ma, Jianwu Dai, Fengzeng Jian   +6 more
doaj   +1 more source