Results 1 to 10 of about 99,862 (252)

CircRNAs in Tumor Radioresistance

Biomolecules, 2022
Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges.
Yining Gao, Jiawen Gao, Fei Lin, Ting Wang, Sitong Huo, Jiefang Wu, Qi Zhou, Chao Zhang   +7 more
doaj   +1 more source

Correlation between Iliac Tilt and traditional sagittal parameters in adolescents

Journal of Orthopaedic Surgery and Research
Objective This study aims to systematically validate the reliability and applicability of Iliac Tilt (IT) as a parameter for sagittal balance assessment, explore its relationship with traditional parameters such as Pelvic Tilt (PT) and Pubic-Sacral Angle
ZengHui Zhao, Hao Qi, Anqi Zhao, Hongru Yuan, Peng Zhang, Chenchen Wang, Chenxi Wang, Di Zhang   +7 more
doaj   +1 more source

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway

Frontiers in Immunology, 2018
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the main components in the Rhizoma of Paris polyphyllin, displays a selective ...
Qiong Wang, Qiong Wang, Qiong Wang, Xin Zhou, Yongjian Zhao, Yongjian Zhao, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Qi Shi, Qi Shi, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Hongyan Wang, Qianqian Liang, Qianqian Liang, Qianqian Liang   +19 more
doaj   +1 more source

Genome-wide translation control analysis of developing human neurons

Molecular Brain, 2022
During neuronal differentiation, neuroprogenitor cells become polarized, change shape, extend axons, and form complex dendritic trees. While growing, axons are guided by molecular cues to their final destination, where they establish synaptic connections
Érico Moreto Lins, Natássia Cristina Martins Oliveira, Osvaldo Reis, Adriano Ferrasa, Roberto Herai, Alysson R. Muotri, Katlin Brauer Massirer, Mário Henrique Bengtson   +7 more
doaj   +1 more source

The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum

mBio, 2021
Malaria remains a major public health and economic burden currently. The mutually exclusive expression of the virulence genes is associated with the pathogenesis and immune evasion of human malaria parasites in the host.
Binbin Lu, Meng Liu, Liang Gu, Ying Li, Shijun Shen, Gangqiang Guo, Fei Wang, Xiaohui He, Yuemeng Zhao, Xiaomin Shang, Liping Wang, Guang Yang, Qianshu Zhu, Jun Cao, Cizhong Jiang, Richard Culleton, Gang Wei, Qingfeng Zhang   +17 more
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Association between vitamin D receptor gene polymorphism (rs731236) and aggrecan gene VNTR polymorphism with the risk of lumbar intervertebral disc degeneration

Caspian Journal of Internal Medicine, 2022
Background: Low back pain is one of the most common causes of referral to physicians. Lumbar disc degeneration (LDD) is the main cause of back pain in different countries. It seems that genetic factors are more effective than environmental factors in the
Kaveh Haddadi, Mohammad Sahebi, Abdolkarim Mahrooz, Masoud Shayestehazar, Mohammad Bagher Hashemi-Soteh   +4 more
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Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model

Bone Research, 2022
Spondylocarpotarsal syndrome (SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions resulting from biallelic nonsense mutations in the gene encoding filamin B (FLNB).
Jennifer Zieba, Kimberly N. Forlenza, Kelly Heard, Jorge H. Martin, Michaela Bosakova, Daniel H. Cohn, Stephen P. Robertson, Pavel Krejci, Deborah Krakow   +8 more
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Structural and molecular distinctions of primary and secondary spines in the sea urchin Lytechinus variegatus

Scientific Reports
Sea urchins (echinoids) are common model organisms for research in developmental biology and for their unusual transition from a bilaterally organized larva into a post-metamorphic adult with pentaradial body symmetry.
Elise Hebert, Madison Silvia, Gary M. Wessel   +2 more
doaj   +1 more source

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy

Advanced Science
Designing drugs to intelligently respond to different ratio of biological electron donors/receptors in cancer cells and normal cells is a promising strategy to achieve highly effective and less toxic chemotherapy.
Xiaoyu Qin, Junxian Guo, Hui Li, Hanlong He, Fei Cai, Xinyan Chen, Mingkai Chen, Tianfeng Chen, Li Ma   +8 more
doaj   +1 more source

Prions activate a p38 MAPK synaptotoxic signaling pathway.

PLoS Pathogens, 2018
Synaptic degeneration is one of the earliest pathological correlates of prion disease, and it is a major determinant of the progression of clinical symptoms.
Cheng Fang, Bei Wu, Nhat T T Le, Thibaut Imberdis, Robert C C Mercer, David A Harris   +5 more
doaj   +1 more source