ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity [PDF]
Recent studies have reported conflicting results regarding the role of ARF6 in dendritic spine development, but no clear answer for the controversy has been suggested.
Kim Y. +6 more
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Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [PDF]
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss.
Fuhrmann Martin +28 more
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Towards molecular systems biology of gene transcription and regulation [PDF]
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
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Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology [PDF]
The use of computational modeling and simulation has increased in many biological fields, but despite their potential these techniques are only marginally applied in nutritional sciences.
Ommen, Ben van +57 more
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TarO : a target optimisation system for structural biology [PDF]
This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434).
Naismith, Jim +44 more
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Study of dendritic spine compartmentalization : a correlative fluorescence light microscopy-electron microscopy approach [PDF]
Neurons communicate with each other through synapses. Most excitatory synapses contact small protrusions called dendritic spines. Spines are connected to dendrites by a very thin stalk called the “spine neck” which restricts diffusion between the spine ...
Cyprien, Vivien
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Intervertebral disc characterization by shear wave elastography: an in-vitro preliminary study [PDF]
Patient-specific numerical simulation of the spine is a useful tool both in clinic and research. While geometrical personalization of the spine is no more an issue, thanks to recent technological advances, non-invasive personalization of soft tissue’s ...
VERGARI, Claudio +7 more
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A Molecular Biology Database Digest [PDF]
Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18].
Kröger, Peer +3 more
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Spine morphology of neurons in the Avian forebrain is affected by rearing conditions [PDF]
Rollenhagen A, Bischof H-J. Spine morphology of neurons in the Avian forebrain is affected by rearing conditions. Behavioral and Neural Biology. 1994;62(2):83-89.An area of the caudal forebrain of male zebra finches, the Archi-Neostriatum caudale (ANC ...
Rollenhagen, Astrid +1 more
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Tunicates push the limits of animal evo-devo [PDF]
The phylum to which humans belong, Chordata, takes its name from one of the major shared derived features of the group, the notochord. All chordates have a notochord, at least during embryogenesis, and there is little doubt about notochord homology at ...
David EK Ferrier +2 more
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