Results 1 to 10 of about 34,461 (100)

Osteoporosis in the Spine: Recent Update in Biology, Molecular Therapy and Management

Journal of Orthopaedic Translation, 2016
doaj   +3 more sources

Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma [PDF]

EJNMMI Research
Background Radiological imaging plays an indispensable role in both preclinical and clinical studies of multiple myeloma (MM). However, manual quantification in longitudinal small animal PET/CT is limited by annotator bias, signal artifacts from urinary ...
Zhixin Sun, Jacqueline M. Godbe, Alexander Zheleznyak, Brad Manion, Junhao Hu, Julie L. Prior, Kathleen Duncan, Ulugbek S. Kamilov, Monica Shokeen   +8 more
doaj   +2 more sources

Structural and molecular distinctions of primary and secondary spines in the sea urchin Lytechinus variegatus [PDF]

Scientific Reports
Sea urchins (echinoids) are common model organisms for research in developmental biology and for their unusual transition from a bilaterally organized larva into a post-metamorphic adult with pentaradial body symmetry.
Elise Hebert, Madison Silvia, Gary M. Wessel   +2 more
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Chronic phospholipase D1 inhibition via small molecule inhibitors ameliorate dendritic spine dystrophy in ADRD mouse models via phosphocofilin mediated changes [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundPhosphatidyl choline phospholipase D (PC‐PLD), a lipolytic enzyme that breaks down membrane phospholipids via two isoforms ‐ a constitutively expressed PLD2 and an inducible PLD1 isoform ‐ are also involved in developmentally important signaling mechanisms that regulate synaptic function.
Carlos X. Medina Perez, Krystyn Z. Bourne, Balaji Krishnan, Chandramouli Natarajan   +3 more
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Placement of Unilateral Cortical Bone Trajectory Screws in Previously Instrumented Pedicle without Removal of Existing Hardware for Adjacent Segment Disease

Case Reports in Orthopedics, 2021
Adjacent segment disease (ASD) in the lumbar spine is a possible consequence in segments adjacent to a fusion. As the number of lumbar fusions in the United States increases, the rates of ASD will continue to climb.
Rojeh Melikian, Sofia Yeremian
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Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells

Stem Cells International, 2022
The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine.
Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao   +10 more
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Diagnosis and treatment of spine and spinal cord tumors in the era of molecular pathological diagnosis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
With the publication of the "2021 World Health Organization Classification of Tumors of the Central Nervous System (fifth edition)" (hereinafter referred to as the 2021 version of tumor classification), a new model of histological and molecular ...
JIAN Feng⁃zeng, WANG Xing⁃wen
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Sa12b Improves Biological Activity of Human Degenerative Nucleus Pulposus Mesenchymal Stem Cells in a Severe Acid Environment by Inhibiting Acid-Sensitive Ion Channels

Frontiers in Bioengineering and Biotechnology, 2022
Sa12b is a wasp peptide that can inhibit acid-sensitive ion channels (ASICs). The biological effects of nucleus pulposus mesenchymal stem cells (NP-MSCs) have not been investigated. Therefore, this study investigated the effect of Sa12b on the biological
Ziyu Wang, Letian Han, Haoyu Chen, Shengquan Zhang, Sumei Zhang, Hua Zhang, Yuhao Li, Hui Tao, Jie Li   +8 more
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Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation

Cell Regeneration, 2022
Long non-coding (lnc) RNA plays important roles in many cellular processes. The function of the vast majority of lncRNAs remains unknown. Here we identified that lncRNA-1700113A16RIK existed in skeletal muscle stem cells (MuSCs) and was significantly ...
Xin Fu, Sheng Li, Minzhi Jia, Bo Xu, Lele Yang, Ruimiao Ma, Hong Cheng, Wenjun Yang, Ping Hu   +8 more
doaj   +1 more source

Single-cell transcriptomics reveals ependymal subtypes related to cytoskeleton dynamics as the core driver of syringomyelia pathological development

iScience, 2023
Summary: Syringomyelia is a common clinical lesion associated with cerebrospinal fluid flow abnormalities. By a reversible model with chronic extradural compression to mimic human canalicular syringomyelia, we explored the spatiotemporal pathological ...
Chunli Lu, Xianming Wu, Xinyu Wang, Zhifeng Xiao, Longbing Ma, Jianwu Dai, Fengzeng Jian   +6 more
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