Results 1 to 10 of about 368,572 (311)

Osteoporosis in the Spine: Recent Update in Biology, Molecular Therapy and Management

Journal of Orthopaedic Translation, 2016
doaj   +4 more sources

Paradoxical signaling regulates structural plasticity in dendritic spines [PDF]

, 2016
Transient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine enlargement have been identified experimentally. Here, we use a systems biology approach to construct a mathematical model of biochemical signaling and ...
Khan, Shahid M., Levy, Michael G., Oster, George, Rangamani, Padmini   +3 more
arxiv   +3 more sources

Structural and molecular distinctions of primary and secondary spines in the sea urchin Lytechinus variegatus [PDF]

Scientific Reports
Sea urchins (echinoids) are common model organisms for research in developmental biology and for their unusual transition from a bilaterally organized larva into a post-metamorphic adult with pentaradial body symmetry.
Elise Hebert, Madison Silvia, Gary M. Wessel   +2 more
doaj   +2 more sources

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

Nature Structural &Molecular Biology, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +2 more sources

Chronic phospholipase D1 inhibition via small molecule inhibitors ameliorate dendritic spine dystrophy in ADRD mouse models via phosphocofilin mediated changes [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundPhosphatidyl choline phospholipase D (PC‐PLD), a lipolytic enzyme that breaks down membrane phospholipids via two isoforms ‐ a constitutively expressed PLD2 and an inducible PLD1 isoform ‐ are also involved in developmentally important signaling mechanisms that regulate synaptic function.
Carlos X. Medina Perez, Krystyn Z. Bourne, Balaji Krishnan, Chandramouli Natarajan   +3 more
openaire   +2 more sources

The effect of synthesized cartilage tissue from human adipose-derived mesenchymal stem cells in orthopedic spine surgery in patients with osteoarthritis.

Cellular and Molecular Biology, 2021
Osteoarthritis is a joint disease that causes degeneration of articular cartilage and involvement of subcutaneous bone and inflammation of surrounding tissues. It can affect any joints, but the most common joints are the joints of the hands, feet, knees,
Weijie Tang, Xinhua Guan, Jingqi Han, XiLing Yin, Feng Zuoji   +4 more
semanticscholar   +1 more source

Placement of Unilateral Cortical Bone Trajectory Screws in Previously Instrumented Pedicle without Removal of Existing Hardware for Adjacent Segment Disease

Case Reports in Orthopedics, 2021
Adjacent segment disease (ASD) in the lumbar spine is a possible consequence in segments adjacent to a fusion. As the number of lumbar fusions in the United States increases, the rates of ASD will continue to climb.
Rojeh Melikian, Sofia Yeremian
doaj   +1 more source

Diagnosis and treatment of spine and spinal cord tumors in the era of molecular pathological diagnosis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
With the publication of the "2021 World Health Organization Classification of Tumors of the Central Nervous System (fifth edition)" (hereinafter referred to as the 2021 version of tumor classification), a new model of histological and molecular ...
JIAN Feng⁃zeng, WANG Xing⁃wen
doaj   +1 more source

Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells

Stem Cells International, 2022
The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine.
Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao   +10 more
doaj   +1 more source

A Dynamic Model of Interactions of Ca^(2+), Calmodulin, and Catalytic Subunits of Ca^(2+)/Calmodulin-Dependent Protein Kinase II [PDF]

, 2010
During the acquisition of memories, influx of Ca^(2+) into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses.
A Hoelz, A Muller, A Persechini, AJ Silva, AJ Silva, B Shapiro, BB Olwin, BB Olwin, BE Finn, BE Finn, DM Santucci, DM Watterson, DX Keller, GD Wyss, GJ Augustine, J Lisman, J Rose, JC Helton, JM Bradshaw, JM Shifman, K Shen, KM Franks, M Maravall, Mary B. Kennedy, MB Kennedy, MB Kennedy, MB Kennedy, MI Stefan, MK Bennett, NE Erondu, OS Rosenberg, P De Koninck, PI Hanson, PJ Sjostrom, R Chattopadhyaya, R Phillips, Rama Ranganathan, RC Malenka, RE Kerr, RJ Colbran, RL Iman, S Kakiuchi, S Linse, S Marino, S Mirzoeva, SE Brown, SG Miller, Shirley Pepke, SM Blower, SR Martin, Stefan Mihalas, T Meyer, Tamara Kinzer-Ursem, TH Crouch, TL Kinzer-Ursem, TR Gaertner, WE Meador, Y Kubota, Y Ouyang, YS Babu, Z Xia   +60 more
core   +10 more sources