Results 41 to 50 of about 104,174 (256)

The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]

, 2016
Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F., Aliaga, E., Díaz-Véliz, G., Fiedler, J.L., Fresno, C., García-Rojo, G., Mora, S., Pacheco, A., Parra, C.S., Parra-Fiedler, N., Rojas, P.S., Tejos, M., Vilches, N.   +12 more
core   +1 more source

A Dynamin-3 Spliced Variant Modulates the Actin/Cortactin-Dependent Morphogenesis of Dendritic Spines [PDF]

, 2005
Immature dendrites extend many actin-rich filopodial structures that can be replaced by synapse-containing dendritic spines as the neuron matures. The large GTPase dynamin-3 (Dyn3) is a component of the postsynapse in hippocampal neurons but its function
Chen, Jing, Gray, Noah W., Kruchten, Anne E., McNiven, Mark A.   +3 more
core   +2 more sources

Gene therapy genetic aspects and possibilities for degenerative diseases of intervertebral disks treatment

Ukrainian Neurosurgical Journal, 2008
At the beginning of 90th past century, due to intensive development of molecular biology and tissue engineering, knowledge accumulation about growth factors influence on the intervertebral disc cells, became possible.
E. G. Pedachenko, K. I. Horbatyuk
doaj   +1 more source

3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries

, 2019
Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the ability to simulate cellular processes using these observed geometries ...
Amaro, Rommie E., de La Beaumelle, Nils Angliviel, Holst, Michael J., Laughlin, Justin G., Lee, Christopher T., McCammon, J. Andrew, Ramamoorthi, Ravi, Rangamani, Padmini   +7 more
core   +1 more source

MicroRNA-9 controls dendritic development by targeting REST [PDF]

, 2014
MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain.
Akerblom, Akerblom, Ameres, Andres, Aoki, Bak, Ballas, Ballas, Barnes, Bartel, Bonev, Bonhoeffer, Bushati, Caceres, Care, Chen, Chen, Coolen, Coolen, Dajas-Bailador, Delaloy, Dieni, Dotti, Ebert, Edbauer, Feng, Fiore, Gao, Gentner, Giraldez, Goslin, Han, Hand, Haramati, Hering, Hitz, Horch, Jan, Jiang, Jorgensen, Kawabe, Kawauchi, Kluiver, Koch, Kolb, Krichevsky, Kruger, Kuwabara, Laemmli, Lagos-Quintana, Lagos-Quintana, Leucht, Liu, Liu, Liu, London, Loya, Luxenhofer, Ma, Madisen, Magill, Mumm, Nadeau, Olena, Ooi, Otaegi, Packer, Parrish, Parrish, Pathania, Polleux, Qin, Rajan, Refojo, Rodriguez, Saito, Sauvageau, Schoenherr, Schratt, Senyuk, Shibata, Simó, Soriano, Spruston, Sudhof, Takemoto-Kimura, Tronche, Urbanska, Wayman, Whitford, Witkos, Wong, Yamamoto, Yao, Yoo, Zhao   +95 more
core   +1 more source

In silico engineering and simulation of RNA interferences nanoplatforms for osteoporosis treating and bone healing promoting

Scientific Reports, 2023
Osteoporosis is a bone condition characterized by reduced bone mineral density (BMD), poor bone microarchitecture/mineralization, and/or diminished bone strength.
Aylar Imanpour, Hanieh Kolahi Azar, Dorna Makarem, Zeinab Nematollahi, Reza Nahavandi, Mohammadreza Rostami, Nima Beheshtizadeh   +6 more
doaj   +1 more source

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Low back pain and osteoarthritis pain: a perspective of estrogen

Bone Research, 2023
Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) degeneration and facet joint osteoarthritis (FJOA) are two common causes of LBP, and both
Huiwen Pang, Shihui Chen, David M. Klyne, David Harrich, Wenyuan Ding, Sidong Yang, Felicity Y. Han   +6 more
doaj   +1 more source

Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]

, 2014
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J, Froemke, Robert C, Gomez, Andrea M   +2 more
core   +1 more source