Results 51 to 60 of about 62,419 (139)

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses

, 2012
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP ...
A Araque, A Destexhe, AG Nikonenko, AL Hodgkin, AM Weber, AM Zhabotinsky, B Katz, B Mouillac, B Sahin, BL Bloodgood, BL Sabatini, BL Sabatini, C Agulhon, C Agulhon, C Fall, C Henneberger, C Koch, CLM Bon, D Dumitriu, D Sochivko, DJ Hagler Jr, DX Keller, E Neher, EB Malarkey, ER Higgins, F Erler, F Helmchen, F Taqatqeh, G Perea, GA Rameau, GL Collingridge, GW Young De, H-K Lee, HJ Koester, HV McCue, I Nikonenko, I Wenker, J Bai, J Boehm, J Garthwaite, J Kang, J Keener, J Lisman, J Marchaland, J Sneyd, J-W Shuai, JA Bibb, JE Lisman, JH Bollmann, JH Bollmann, JT Porter, Kaushik Majumdar, KD Micheva, KG Phillips, KM Franks, KT Blackwell, L-C Ching, L-Y Wang, LC Griffith, M Mazzanti, M Pittà De, M Tsodyks, MS Jafri, N Aslam, NC Danbolt, NJ Emptage, P Bezzi, P Miller, PP Atluri, R Anwyl, R Bertram, R Llinas, R Schneggenburger, R Schneggenburger, R Vargas, RA Hopper, RC Malenka, RF Fox, RP Munton, S Ben Achour, S Nadkarni, S Nadkarni, Shivendra Tewari, SJ Taylor, T Ishikawa, TA Fiacco, TP Jensen, TVP Bliss, TVP Bliss, V Calabrese, V Montana, V Parpura, V Parpura, V Volman, WT Coffey, Y Watanabe, Y-X Li, Z Nusser   +97 more
core   +1 more source

The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]

, 2017
Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F., Aliaga, E., Díaz-Véliz, G., Fiedler, J.L., Fresno, C., García-Rojo, G., Mora, S., Pacheco, A., Parra, C.S., Parra-Fiedler, N., Rojas, P.S., Tejos, M., Vilches, N.   +12 more
core   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G. Moreels, Joris Messens, Ana Beloqui   +9 more
wiley   +1 more source

Process-oriented Iterative Multiple Alignment for Medical Process Mining

, 2017
Adapted from biological sequence alignment, trace alignment is a process mining technique used to visualize and analyze workflow data. Any analysis done with this method, however, is affected by the alignment quality.
Burd, Randall S., Chen, Shuhong, Marsic, Ivan, Yang, Sen, Zhou, Moliang   +4 more
core   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks

Advanced Materials, EarlyView.
3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger, Thomas Caganek, Xingzao Wang, Yutong Yin, Khoa Chung, Linna Zhou, Hagan Bayley, Ravinash Krishna Kumar   +7 more
wiley   +1 more source

Retrospective Review on Reticular Materials: Facts and Figures Over the Last 30 Years

Advanced Materials, EarlyView.
To shape the future course of research in reticular materials, this work reflects on the progress over the past 30 years, complemented by input from the community of 228 active researchers through a global, crowdsourced survey: ranging from demographics, how it works, publish and interact, to highlights on both academic and industrial milestones, as ...
Aamod V. Desai, Stefano Canossa, Ekaterina A. Chernova, Simon M. Vornholt, Konstantin Stracke, Jack D. Evans, E. Eja Petersen, Stefan Wuttke, Romy Ettlinger   +8 more
wiley   +1 more source