Results 81 to 90 of about 6,769 (246)
Advanced Science, Volume 11, Issue 15, April 17, 2024.The potassium channel Slack is highly expressed in sensory neurons that sense itch. In this study, several new compounds that activate Slack are developed. It is found that the lead molecule, compound 6, effectively inhibits scratching elicited by multiple pruritogens in mice establishing Slack activation as a novel pharmacological strategy for the ...
Annika Balzulat +20 more
wiley +1 more source
Blockade D2 dopamine receptors as a new approach to correction of violations in alveolar parenchyma and regulation of endothelial progenitor cells in pulmonary emphysema [PDF]
, 2018 On the model of emphysema of the lungs caused by an extract of cigarette smoke or elastase, it was shown that spiperone has an anti-inflammatory effect, reduces the area of emphysema, stimulates the regeneration of alveolar cells and the microvascular ...
Жукова, М. А. +2 more
core
Discrimination and Quantification of Glomerular Receptor Subtypes for Atrial Natriuretic Factor (Anf) [PDF]
, 1991 Binding sites for atrial natriuretic factor (ANF) were determined on isolated rat glomeruli as well as on glomerular membranes. To define optimal conditions, binding of ANF was investigated varying incubation time, temperature and protein concentration ...
Gerbes, Alexander L. +2 more
core +1 more source
Neuropsychopharmacology Reports, Volume 44, Issue 1, Page 17-28, March 2024.The structural equation model of the relationships between rejectionsensitivity (RS) and anxious‐depressive attack (ADA). RS contributes significantly to the onset of ADA. Abstract This paper aimed to find clues to treatment‐resistant depression (TRD) solutions.
Hisanobu Kaiya
wiley +1 more source
Elevated Cholesterol in the Coxiella burnetii Intracellular Niche Is Bacteriolytic [PDF]
, 2017 Coxiella burnetii is an intracellular bacterial pathogen and a significant cause of culture-negative endocarditis in the United States. Upon infection, the nascent Coxiella phagosome fuses with the host endocytic pathway to form a large lysosome-like ...
Barbara Burleigh +5 more
core +2 more sources
Neuropsychopharmacology Reports, Volume 44, Issue 1, Page 197-205, March 2024.Chronic haloperidol impacts fear memory differently than single doses. Our study unveils how chronic D2R antagonist treatment alters fear memory expression and extinction in rats, offering crucial insights into potential therapeutic approaches for fear memory disorders.
Kosuke Enomoto +7 more
wiley +1 more source
Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAa receptor B3 subunit genes [PDF]
, 2004 Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor ￢3 subunit (GABRB3) genes.
Bandura +87 more
core +2 more sources
Fluorescent Tools for the Imaging of Dopamine D2‐Like Receptors**
ChemBioChem, Volume 25, Issue 2, January 15, 2024.In this study, we have identified UR‐MN212 (20), a spiperone‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D2R. The binding affinity in the single‐digit nanomolar range could be determined in radioligand competition binding and molecular brightness studies at D2‐like receptors.
Martin Nagl +11 more
wiley +1 more source
, 2012 The transport of compounds around the body has been a topic of interest for many years, and the advent of non-invasive biological imaging in living tissue has made huge advances in the characterisation and localisation of cellular receptors for use in ...
Casey, Duncan Robert +1 more
core +1 more source
Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives [PDF]
, 2014 Aminoindanes, piperazines, and pipradrol derivatives are novel psychoactive substances found in "Ecstasy" tablets as replacements for 3,4-methylenedioxymethamphetamine (MDMA) or substances sold as "ivory wave." The pharmacology of these MDMA- and ...
Hoener, Marius C. +4 more
core +1 more source