Results 111 to 120 of about 3,034,026 (343)

Rationalized design, synthesis and pharmacological screening of amino acid linked spiro pyrrolidino oxyindole analogs through environment friendly reaction

Journal of Advanced Pharmaceutical Technology & Research, 2013
Introduction: The development of newer synthetic approaches toward the synthesis of polynuclear heteroaromatics and their application in the synthesis of some biologically active compounds has been discussed in this study.
Sanjit Kumar Das, Sanjib Bhattacharya, Amit Kundu   +2 more
doaj   +1 more source

spiro-Compounds. Part I.

, 1931
spiro-Compounds. Part I.
openaire   +1 more source

Direct Access to α,β‐Unsaturated γ‐Lactams via Palladium‐Catalysed Carbonylation of Propargylic Ureas.

Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract Additive carbonylations typically necessitate strong nucleophiles, such as alcohols or amines. In this study, we carbonylated a poorly nucleophilic urea, under oxidant‐free conditions. Our straightforward carbonylative strategy enables access to versatile α,β‐unsaturated γ‐lactams featuring an aminocarbonyl fragment, utilizing readily ...
Debora Schiroli, Aleksandr Voronov, Francesco Pancrazzi, Nunzio Iraci, Salvatore Vincenzo Giofrè, Beatrice Macchi, Valeria Stefanizzi, Raffaella Mancuso, Bartolo Gabriele, Paolo Pio Mazzeo, Luca Capaldo, Nicola Della Ca'   +11 more
wiley   +1 more source

On the singular loci and the images of proper holomorphic maps from pseudoellipsoids [PDF]

arXiv, 2014
We prove a generalisation of Rudin's theorem on proper holomorphic maps from the unit ball to the case of proper holomorphic maps from pseudoellipsoids.
arxiv  

Defining Resonance Raman Spectral Responses to Substrate Binding by Cytochrome P450 from \u3cem\u3ePseudomonas putida\u3c/em\u3e [PDF]

, 2008
Resonance Raman spectra are reported for substrate-free and camphor-bound cytochrome P450cam and its isotopically labeled analogues that have been reconstituted with protoheme derivatives that bear -CD3 groups at the 1, 3, 5, and 8-positions (d12 ...
Deng, Tianjing, Kaluka, Daniel, Kincaid, James R., Mak, Piotr J., Manyumwa, Munyaradzi Edith, Zhang, Haiqing   +5 more
core   +1 more source

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

Advanced Synthesis &Catalysis, EarlyView.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso, Israel Carreira‐Barral, Roberto Quesada, María García‐Valverde   +3 more
wiley   +1 more source

Spiro Compounds

Spiro Compounds, 2022
Marta Meazza
semanticscholar   +1 more source

Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification

Scientific Reports, 2016
The spiro[pyrrolidine-3, 3´-oxindole] moiety is present as a core in number of alkaloids with substantial biological activities. Here in we report design and synthesis of a library of compounds bearing spiro[pyrrolidine-3, 3´-oxindole] motifs that ...
Santanu Hati, Sayantan Tripathy, P. K. Dutta, R. Agarwal, R. Srinivasan, Ashutosh Kumar Singh, Shailja Singh, Subhabrata Sen   +7 more
semanticscholar   +1 more source

Synthesis of spirolactones from carbonyls via carboborylation of N‐sulfonylhydrazones with alkoxycarbonylalkylboronic acids

Advanced Synthesis &Catalysis, Accepted Article.
A straightforward synthesis of spirolactones from carbonyls via N‐tosylhydrazones is described. The process consist in the reaction between the N‐tosylhydrazone and ethoxycarbonylethylboronic acid or ethoxycarbonylpropylboronic acid, leading to spiro γ‐butyrolactones or δ‐valerolactones respectively. The transformation takes place by carboborylation of
Lucía López, Sara Filgueira, María-Paz Cabal, Alfonso Carlos Valdés-Gómez   +3 more
wiley   +1 more source

Scalar-tensor $σ$-cosmologies [PDF]

arXiv, 2000
We show that the scalar-tensor $\sigma$-model action is conformally equivalent to general relativity with a minimally coupled wavemap with a particular target metric. Inflation on the source manifold is then shown to occur in a natural way due both to the arbitrary curvature couplings and the wavemap self-interactions.
arxiv