Results 41 to 50 of about 10,792 (98)

Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Neratinib is an oral pan HER inhibitor, that irreversibly inhibits EGFR and HER2 and was proven to be effective against multiple EGFR mutations. In previous study, we reported spiro [indoline-3, 4′-piperidine]-2-ones as anticancer agents.
Lianbao Ye, Tao Zhao, Wenjun Du, Anhu Li, Wei Gao, Jingrong Li, Ling Wang, Weiqiang Chen   +7 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of New Benzoxaborole Derivatives as Potential Antimycobacterial Agents

Medical Sciences Forum, 2022
The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents.
Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová   +7 more
doaj   +1 more source

A Facile One-Pot Construction of Succinimide-Fused Spiro[Pyrrolidine-2,3′-Oxindoles] via 1,3-Dipolar Cycloaddition Involving 3-Amino Oxindoles and Maleimides

Molecules, 2018
Increasing interests have been invested in the development of synthetic strategies toward the construction of spiro[pyrrolidine-2,3′-oxindole], which is the core structural skeleton in some compounds with diverse biological activities.
Lunqiang Jin, Feng Liang
doaj   +1 more source

New spiro (thio) barbiturates based on cyclohexanone and bicyclo [3.1.1]heptan-6-one by nonconcerted [1+5] cycloaddition reaction and their conformational structures

Bulletin of the Chemical Society of Ethiopia, 2014
Crossed-aldol condensation reaction of aromatic aldehydes with ketones such as; acetone and cyclohexanone leads to the efficient formation of cross conjugated α,β-unsaturated ketones in excellent yield.
N. N. Pesyan, S. Noori, S. Poorhassan, E. Şahin   +3 more
doaj   +1 more source

Rationalized design, synthesis and pharmacological screening of amino acid linked spiro pyrrolidino oxyindole analogs through environment friendly reaction

Journal of Advanced Pharmaceutical Technology & Research, 2013
Introduction: The development of newer synthetic approaches toward the synthesis of polynuclear heteroaromatics and their application in the synthesis of some biologically active compounds has been discussed in this study.
Sanjit Kumar Das, Sanjib Bhattacharya, Amit Kundu   +2 more
doaj   +1 more source

Antibacterial Properties of 3 H-Spiro[1-benzofuran-2,1’-cyclohexane] Derivatives from Heliotropium filifolium

Molecules, 2008
A re-examination of cuticular components of Heliotropium filifolium allowed the isolation of four new compounds: 3’-hydroxy-2’,2’,6’-trimethyl-3H-spiro[1-benzo-furan-2,1’-cyclohexane]-5-carboxylic acid(2), methyl 3†...
Marcela Wilkens, Marcos C. Rezende, Javier Echeverría, Alejandro Urzúa   +3 more
doaj  

Synthesis and Crystal Structures of Two Novel O, N-Containing Spiro Compounds

Crystals, 2016
Two novel O, N-containing spiro compounds, C16H16ClNO4 (1) and C16H16N2O6 (2), were prepared by reactions of monosubstituted benzenamine (substituent = –NO2, –Cl) and 1,5-dioxaspiro[5.5]undecane-2,4-dione in ethanol solution of trimethoxymethane.
Wulan Zeng, Jinhe Jiang
doaj   +1 more source

Substituent Effects on the Stability and Antioxidant Activity of Spirodiazaselenuranes

Molecules, 2015
Spirodiazaselenuranes are structurally interesting compounds and the stability of these compounds depends highly on the nature of the substituents attached to the nitrogen atoms.
Devappa S. Lamani, Debasish Bhowmick, Govindasamy Mugesh   +2 more
doaj   +1 more source

Highly congested spiro-compounds via photoredox-mediated dearomative annulation cascade. [PDF]

Commun Chem, 2022
Zhou C, Shatskiy A, Temerdashev AZ, Kärkäs MD, Dinér P.   +4 more
europepmc   +1 more source

3'-R-Spiro[cycloalkyl-1(2), (hetaryl-3(4), 6'-[1,2,4]triazino[2,3-c]quinazoline]-2'(7'H)-2-оnes as a perspective class of compounds with actoprotective activity

Zaporožskij Medicinskij Žurnal, 2017
Quinazolines and their derivatives are a perspective class of compounds with versatile biological activities. Their representatives are used in medical practice as sleeping, diuretic, antimicrobial and antitumor drugs.
O. S. Kolomoets, О. Yu. Voskoboynik, I. S. Nosulenko, O. V. Krivoshey, A. I. Avramenko, G. G. Berest, S. I. Kovalenko   +6 more
doaj   +1 more source