Results 1 to 10 of about 61,341 (287)

Effect of spironolactone use in pulmonary arterial hypertension – analysis from pivotal trial databases [PDF]

Pulmonary Circulation, 2021
Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type‐B receptor function within pulmonary ...
Zeenat Safdar, Eunah Cho
doaj   +2 more sources

Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial

Clinical and Translational Science, 2022
This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mildly reduced ...
Iain B. Squire, Anders Gabrielsen, Peter J. Greasley, Linda Wernevik, Judith Hartleib‐Geschwindner, Julie Holden, Susanne Johansson, Anna Rudvik, José Sánchez, Krister Bamberg, Johanna Melin, Andrew Whittaker   +11 more
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The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

Clinical, Cosmetic and Investigational Dermatology, 2023
Chaofan Wang, Yimei Du, Lingbo Bi, Xuewen Lin, Min Zhao, Weixin Fan Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Weixin Fan, Department of Dermatology, The ...
Wang C, Du Y, Bi L, Lin X, Zhao M, Fan W
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Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study

Acta Dermato-Venereologica
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne.
Brigitte Dréno, Jean-Michel Nguyen, Ewa Hainaut, Laurent Machet, Marie-Thérèse Leccia, Nathalie Beneton, Jean-Paul Claudel, Philippe Célérier, Marie Le Moigne, Sarah Le Naour, Florence Vrignaud, Alexandra Poinas, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Simon Korner, Amir Khammari   +16 more
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Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea

Frontiers in Medicine, 2021
Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.
Dongsub Jeon, Minkook Son, Jonggi Choi
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Outcomes of Spironolactone Withdrawal in Dilated Cardiomyopathy With Improved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Background: The feasibility of spironolactone withdrawal in dilated cardiomyopathy patients with improved ejection fraction remains unknown. This study sought to determine whether spironolactone can be withdrawn safely in this circumstance.Methods ...
Yanjia Chen, Yanjia Chen, Zeping Qiu, Zeping Qiu, Jie Jiang, Xiuxiu Su, Fanyi Huang, Fanyi Huang, Jing Tang, Wei Jin, Wei Jin   +10 more
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Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes [PDF]

International Urology and Nephrology, 2019
PurposePodocytes are terminally differentiated cells lining the Bowman’s capsule. Podocytes are critical for the proper glomerular filtration barrier function.
Dan Dong, Ting-ting Fan, Ying-shi Ji, Jinyuan Yu, Shan Wu, Li Zhang   +5 more
semanticscholar   +2 more sources

Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling [PDF]

Frontiers in Physiology, 2015
Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2.
Marcondes Alves Barbosa Da Silva, Thiago eBruder-Nascimento, Stêfany Bruno De Assis Cau, Rheure AM Lopes, Fabiola LAC Mestriner, Rafael S Fais, Rhian M Touyz, Rita C Tostes   +7 more
doaj   +5 more sources

Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes.
Sudeep R. Aryal, Mohammed Siddiqui, Oleg F. Sharifov, Megan D. Coffin, Bin Zhang, Krishna K. Gaddam, Himanshu Gupta, Thomas S. Denney, Louis J. Dell'Italia, Suzanne Oparil, David A. Calhoun, Steven G. Lloyd   +11 more
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A systematic review and meta-analysis of effects of spironolactone on blood pressure, glucose, lipids, renal function, fibrosis and inflammation in patients with hypertension and diabetes

Blood Pressure, 2021
Purpose Hypertension commonly co-exists with diabetes mellitus (DM), and both are closely related to adverse health outcomes. The activation of aldosterone and mineralocorticoid receptor (MR) may play important roles in this process. Therefore, we aim to
Mengyue Lin, Mulalibike Heizati, Lin Wang, Muyesaier Nurula, Zhikang Yang, Zhongrong Wang, Reyila Abudoyreyimu, Zihao Wu, Nanfang Li   +8 more
doaj   +2 more sources