Results 11 to 20 of about 50,141 (259)
Effect of spironolactone use in pulmonary arterial hypertension – analysis from pivotal trial databases [PDF]
Pulmonary Circulation, 2021 Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type‐B receptor function within pulmonary ...
Zeenat Safdar, Eunah Cho
doaj +2 more sources
Clinical and Translational Science, 2022 This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mildly reduced ...
Iain B. Squire +11 more
doaj +2 more sources
Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling [PDF]
Frontiers in Physiology, 2015 Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2.
Marcondes Alves Barbosa Da Silva +7 more
doaj +5 more sources
Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]
, 2017 Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A +4 more
core +5 more sources
Blood Pressure, 2021 Purpose Hypertension commonly co-exists with diabetes mellitus (DM), and both are closely related to adverse health outcomes. The activation of aldosterone and mineralocorticoid receptor (MR) may play important roles in this process. Therefore, we aim to
Mengyue Lin +8 more
doaj +2 more sources
Anti-Fibrosis Effect of Relaxin and Spironolactone Combined on Isoprenaline-Induced Myocardial Fibrosis in Rats via Inhibition of Endothelial–Mesenchymal Transition [PDF]
Cellular Physiology and Biochemistry, 2017 Background: The effect of relaxin and spironolactone combined on myocardial fibrosis has not been reported. Thus, we investigated the effect of the combined therapy on isoprenaline-induced myocardial fibrosis and the mechanism.
Jiejie Cai +6 more
doaj +2 more sources
Effects of Spironolactone on Proteinuria of Patients with Type 2 Diabetes [PDF]
مجله دانشکده پزشکی اصفهان, 2012 Background: Diabetic nephropathy is the most common cause of kidney failure. We investigated the beneficial effects of spironolactone, alone and in combination with hydrochlorothiazide, on diabetic nephropathy.
Mohamad Karami Horestani +3 more
doaj +2 more sources
Pharmacotherapy of patients with atrial fibrillation and restored sinus rhythm – is the medication with spironolactone beneficial in this case? [PDF]
Pharmacia, 2021 Objective: Atrial fibrillation is progressive disease with important health consequences, in which fibrosis is a key player. The aim of our study is to assess the effect of mineralcorticoid blockade on top of standard treatment in patients with atrial ...
Antoniya Kisheva +2 more
doaj +3 more sources
International Journal of Women's DermatologyBackground:. Hidradenitis suppurativa (HS) is a chronic skin disease characterized by recurrent nodules that affect areas with a high density of apocrine sweat glands, such as the axillae and groin.
Suma V. Gangidi, BS +4 more
doaj +2 more sources
Journal of Pain and Symptom Management, 2017 Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on www.palliativedrugs.com. Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and
Laura Carone +5 more
+5 more sources