Results 11 to 20 of about 50,320 (220)

Effect of spironolactone use in pulmonary arterial hypertension – analysis from pivotal trial databases [PDF]

Pulmonary Circulation, 2021
Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type‐B receptor function within pulmonary ...
Zeenat Safdar, Eunah Cho
doaj   +2 more sources

SPIRONOLACTONE FOR NONRESOLVING CENTRAL SEROUS CHORIORETINOPATHY: A RANDOMIZED CONTROLLED CROSSOVER STUDY. [PDF]

, 2015
PURPOSE: To evaluate the effect of spironolactone, a mineralocorticoid receptor antagonist, for nonresolving central serous chorioretinopathy. METHODS: This is a prospective, randomized, double-blinded, placebo-controlled crossover study. Sixteen eyes of
Batista, R., Behar-Cohen, F., Bergin, C., Beydoun, T., Bousquet, E., Brandely, M.L., Chast, F., Couraud, B., Farman, N., Gaudric, A., Rothschild, P.R., Zhao, M.   +11 more
core   +6 more sources

Efficacy of spironolactone in treating hidradenitis suppurativa in women of childbearing age: a single-center retrospective analysis

International Journal of Women's Dermatology
Background:. Hidradenitis suppurativa (HS) is a chronic skin disease characterized by recurrent nodules that affect areas with a high density of apocrine sweat glands, such as the axillae and groin.
Suma V. Gangidi, BS, Rachel K. Greene, MD, Eric Olsen, MD, Shanelle Jackson, BS, Mio Nakamura, MD   +4 more
doaj   +2 more sources

Finerenone versus spironolactone in patients with chronic kidney disease and type 2 diabetes: a target trial emulation. [PDF]

Nat Commun
Wang CA, Lai HW, Chen JY, Wang WJ, Lin LC, Chiu YL, Cheng CY, Wu VC.   +7 more
europepmc   +3 more sources

Retrospective analysis of adverse events with spironolactone in females reported to the United States Food and Drug Administration

International Journal of Women's Dermatology, 2020
Background: Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective: This study aimed to classify the most common adverse reactions associated with spironolactone in women of ...
Yu Wang, BA, Shari R. Lipner, MD, PhD
doaj   +1 more source

Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea

Frontiers in Medicine, 2021
Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.
Dongsub Jeon, Minkook Son, Jonggi Choi
doaj   +1 more source

Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial

Clinical and Translational Science, 2022
This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mildly reduced ...
Iain B. Squire, Anders Gabrielsen, Peter J. Greasley, Linda Wernevik, Judith Hartleib‐Geschwindner, Julie Holden, Susanne Johansson, Anna Rudvik, José Sánchez, Krister Bamberg, Johanna Melin, Andrew Whittaker   +11 more
doaj   +1 more source

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]

, 2017
Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A, Elliott, J, Hezzell, M J, Lopez-Alvarez, J, Lotter, N S   +4 more
core   +3 more sources

Association of spironolactone treatment and arterial stiffness and cardiovascular disease in hypertensive patients

Archives of Medical Science, 2019
Introduction The aim of the current study was to evaluate the association of spironolactone and arterial stiffness and composite cardiovascular disease (CVD, including coronary heart disease, congestive heart failure and ischemic stroke) in hypertensive ...
Fanfang Zeng, Rong Huang, Yongkang Lu, Zhiye Wu, Weiyi Mai, Lili Wang   +5 more
doaj   +1 more source

Effects of Low-Dose Spironolactone Combined with Metformin or Either Drug Alone on Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Pilot Study

International Journal of Endocrinology, 2022
Metformin and spironolactone alone can be used for the management of polycystic ovarian syndrome (PCOS), and their combination could result in even better outcomes.
Tao Long, Ying Zhang, Chunping Zeng, Siyuan Zheng, Lin Zhou, Haiyan Liu   +5 more
doaj   +1 more source