Results 11 to 20 of about 61,341 (287)

Anti-Fibrosis Effect of Relaxin and Spironolactone Combined on Isoprenaline-Induced Myocardial Fibrosis in Rats via Inhibition of Endothelial–Mesenchymal Transition [PDF]

Cellular Physiology and Biochemistry, 2017
Background: The effect of relaxin and spironolactone combined on myocardial fibrosis has not been reported. Thus, we investigated the effect of the combined therapy on isoprenaline-induced myocardial fibrosis and the mechanism.
Jiejie Cai, Xiao Chen, Xingxing Chen, Lingzhi Chen, Gaoshu Zheng, Hao Zhou, Xi Zhou   +6 more
doaj   +2 more sources

Efficacy and Safety of Low‐Dose Spironolactone in Management of Diabetic Kidney Disease in a Real‐World Setting [PDF]

Endocrinology, Diabetes & Metabolism
Background Adding spironolactone to renin‐angiotensin‐aldosterone system (RAAS) blockers has been shown to reduce albuminuria in patients with diabetic kidney disease (DKD). However, the increased risk of hyperkalaemia is a major concern.
Manochehr Amini, Davood Dalil, Fatemeh Yaghoubi, Zoleykha Valizadeh, Farnaz Tavakoli, Zohreh Koohpayezadeh   +5 more
doaj   +2 more sources

Effects of Spironolactone on Proteinuria of Patients with Type 2 Diabetes [PDF]

مجله دانشکده پزشکی اصفهان, 2012
Background: Diabetic nephropathy is the most common cause of kidney failure. We investigated the beneficial effects of spironolactone, alone and in combination with hydrochlorothiazide, on diabetic nephropathy.
Mohamad Karami Horestani, Saeed Behradmanesh, Ali Momeni, Azar Baradaran   +3 more
doaj   +2 more sources

Pharmacotherapy of patients with atrial fibrillation and restored sinus rhythm – is the medication with spironolactone beneficial in this case? [PDF]

Pharmacia, 2021
Objective: Atrial fibrillation is progressive disease with important health consequences, in which fibrosis is a key player. The aim of our study is to assess the effect of mineralcorticoid blockade on top of standard treatment in patients with atrial ...
Antoniya Kisheva, Yoto Yotov, Evgeni Grigorov   +2 more
doaj   +3 more sources

Changes in frailty based on minimally important difference and the impact of spironolactone on frailty in heart failure with preserved ejection fraction: insights from the TOPCAT trial. [PDF]

Open Heart
Tang Y, Li W, Wang Z, Chu SH, Wu Y, Jia Z, Hua C, Zhang H, Liu X, Lv Q, Jiang C, Dong JZ, Ma CS, Du X.   +13 more
europepmc   +3 more sources

Efficacy of spironolactone in treating hidradenitis suppurativa in women of childbearing age: a single-center retrospective analysis

International Journal of Women's Dermatology
Background:. Hidradenitis suppurativa (HS) is a chronic skin disease characterized by recurrent nodules that affect areas with a high density of apocrine sweat glands, such as the axillae and groin.
Suma V. Gangidi, BS, Rachel K. Greene, MD, Eric Olsen, MD, Shanelle Jackson, BS, Mio Nakamura, MD   +4 more
doaj   +2 more sources

Determination and Occurrence of Mineralocorticoids in Taihu Lake of China

Frontiers in Environmental Science, 2021
We developed a sensitive method for monitoring six natural (aldosterone) and synthetic mineralocorticoids (canrenone, spironolactone, 7β-spironolactone, 7α-thio spironolactone, and 7α-thiomethyl spironolactone) in sediment and water using ultra ...
Li Zhao, Hong Chang, Fuhong Sun, Hailei Su   +3 more
doaj   +1 more source

Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial

British medical journal, 2023
Objective To assess the effectiveness of oral spironolactone for acne vulgaris in adult women. Design Pragmatic, multicentre, phase 3, double blind, randomised controlled trial.
M. Santer, M. Lawrence, S. Renz, Z. Eminton, B. Stuart, T. Sach, Sarah Pyne, M. Ridd, Nick Francis, I. Soulsby, Karen Thomas, N. Permyakova, P. Little, I. Muller, J. Nuttall, G. Griffiths, K. Thomas, A. Layton   +17 more
semanticscholar   +1 more source

Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction

Cells, 2022
Mitral regurgitation (MR), the disruption of the mitral valve, contributes to heart failure (HF). Under conditions of volume overload, excess mineralocorticoids promote cardiac fibrosis.
Wei-Ting Chang, Yu-Wen Lin, Chin-Yu Chen, Zhih-Cherng Chen, Jhih-Yuan Shih, Chia-Ching Wu, Chwan-Yau Luo, Ping-Yen Liu   +7 more
doaj   +1 more source

A comparative post hoc analysis of finerenone and spironolactone in resistant hypertension in moderate-to-advanced chronic kidney disease

Clinical Kidney Journal, 2022
Background Mineralocorticoid receptor antagonists (MRAs) reduce systolic blood pressure (SBP) and increase serum potassium concentration ([K+]).
R. Agarwal, B. Pitt, B. Palmer, C. Kovesdy, Ellen Burgess, G. Filippatos, J. Małyszko, L. Ruilope, P. Rossignol, P. Rossing, R. Pecoits-Filho, S. Anker, A. Joseph, R. Lawatscheck, D. Wilson, M. Gebel, G. Bakris   +16 more
semanticscholar   +1 more source