Results 21 to 30 of about 50,141 (259)

Spotlight on Spironolactone Oral Suspension for the Treatment of Heart Failure: Focus on Patient Selection and Perspectives

Vascular Health and Risk Management, 2019
Antonis A Manolis,1 Theodora A Manolis,2 Helen Melita,3 Antonis S Manolis4 1Patras University School of Medicine, Patras, Greece; 2Red Cross Hospital, Athens, Greece; 3Onassis Cardiac Surgery Center, Athens, Greece; 4Athens University School of Medicine,
Manolis AA, Manolis TA, Melita H, Manolis AS   +3 more
doaj   +1 more source

Determination and Occurrence of Mineralocorticoids in Taihu Lake of China

Frontiers in Environmental Science, 2021
We developed a sensitive method for monitoring six natural (aldosterone) and synthetic mineralocorticoids (canrenone, spironolactone, 7β-spironolactone, 7α-thio spironolactone, and 7α-thiomethyl spironolactone) in sediment and water using ultra ...
Li Zhao, Hong Chang, Fuhong Sun, Hailei Su   +3 more
doaj   +1 more source

Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction

Cells, 2022
Mitral regurgitation (MR), the disruption of the mitral valve, contributes to heart failure (HF). Under conditions of volume overload, excess mineralocorticoids promote cardiac fibrosis.
Wei-Ting Chang, Yu-Wen Lin, Chin-Yu Chen, Zhih-Cherng Chen, Jhih-Yuan Shih, Chia-Ching Wu, Chwan-Yau Luo, Ping-Yen Liu   +7 more
doaj   +1 more source

The Effect of Spironolactone on β-amyloid-Induced Memory Impairment in Male Rats: The Role of Microglial Inhibition [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Neuroinflammation was indicated in the pathophysiology of Alzheimer’s disease(AD). Previous reports have also signified that spironolactone has anti-inflammatory effects.Therefore, the aim of this study was to assess the modulatory effects of ...
Mohammad Mehdipour, Masoumeh Emamghoreishi, Majid Reza Farrokhi, Elahe Amirinezhadfard, Mojtaba Keshavarz   +4 more
doaj   +1 more source

Efficacy of Spironolactone as an Adjunctive Therapy to Risperidone to Improve Symptoms of Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial

Iranian Journal of Psychiatry, 2021
Objective: Spironolactone (C24H32O4S), a potent mineralocorticoid receptor (MR) inhibitor, is a potassium-sparing diuretic that is traditionally used to treat fluid build-up in the body or for its anti-androgenic properties. This study is a double-blind,
Atefeh Zandifar, Rahim Badrfam, Hossein Sanjari Moghaddam, Shahin Akhondzadeh   +3 more
doaj   +1 more source

Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence

Biomedicines, 2022
We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients.
Laura E. J. Peeters, Leonardien K. Tjong, Wim J. R. Rietdijk, Teun van Gelder, Birgit C. P. Koch, Jorie Versmissen   +5 more
doaj   +1 more source

Retrospective analysis of adverse events with spironolactone in females reported to the United States Food and Drug Administration

International Journal of Women's Dermatology, 2020
Background: Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective: This study aimed to classify the most common adverse reactions associated with spironolactone in women of ...
Yu Wang, BA, Shari R. Lipner, MD, PhD
doaj   +1 more source

Changes in frailty based on minimally important difference and the impact of spironolactone on frailty in heart failure with preserved ejection fraction: insights from the TOPCAT trial. [PDF]

Open Heart
Tang Y, Li W, Wang Z, Chu SH, Wu Y, Jia Z, Hua C, Zhang H, Liu X, Lv Q, Jiang C, Dong JZ, Ma CS, Du X.   +13 more
europepmc   +3 more sources

Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea

Frontiers in Medicine, 2021
Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.
Dongsub Jeon, Minkook Son, Jonggi Choi
doaj   +1 more source

Association of spironolactone treatment and arterial stiffness and cardiovascular disease in hypertensive patients

Archives of Medical Science, 2019
Introduction The aim of the current study was to evaluate the association of spironolactone and arterial stiffness and composite cardiovascular disease (CVD, including coronary heart disease, congestive heart failure and ischemic stroke) in hypertensive ...
Fanfang Zeng, Rong Huang, Yongkang Lu, Zhiye Wu, Weiyi Mai, Lili Wang   +5 more
doaj   +1 more source