Results 21 to 30 of about 61,341 (287)

The Effect of Spironolactone on β-amyloid-Induced Memory Impairment in Male Rats: The Role of Microglial Inhibition [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Neuroinflammation was indicated in the pathophysiology of Alzheimer’s disease(AD). Previous reports have also signified that spironolactone has anti-inflammatory effects.Therefore, the aim of this study was to assess the modulatory effects of ...
Mohammad Mehdipour, Masoumeh Emamghoreishi, Majid Reza Farrokhi, Elahe Amirinezhadfard, Mojtaba Keshavarz   +4 more
doaj   +1 more source

Spotlight on Spironolactone Oral Suspension for the Treatment of Heart Failure: Focus on Patient Selection and Perspectives

Vascular Health and Risk Management, 2019
Antonis A Manolis,1 Theodora A Manolis,2 Helen Melita,3 Antonis S Manolis4 1Patras University School of Medicine, Patras, Greece; 2Red Cross Hospital, Athens, Greece; 3Onassis Cardiac Surgery Center, Athens, Greece; 4Athens University School of Medicine,
Manolis AA, Manolis TA, Melita H, Manolis AS   +3 more
doaj   +1 more source

Association of Spironolactone Use With Risk of Cancer: A Systematic Review and Meta-analysis.

JAMA dermatology, 2022
Importance While originally approved for the management of heart failure, hypertension, and edema, spironolactone is commonly used off label in the management of acne, hidradenitis, androgenetic alopecia, and hirsutism. However, spironolactone carries an
K. Bommareddy, Hassan Hamade, M. Lopez-Olivo, M. Wehner, Traci Tosh, J. Barbieri   +5 more
semanticscholar   +1 more source

Efficacy of Spironolactone as an Adjunctive Therapy to Risperidone to Improve Symptoms of Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial

Iranian Journal of Psychiatry, 2021
Objective: Spironolactone (C24H32O4S), a potent mineralocorticoid receptor (MR) inhibitor, is a potassium-sparing diuretic that is traditionally used to treat fluid build-up in the body or for its anti-androgenic properties. This study is a double-blind,
Atefeh Zandifar, Rahim Badrfam, Hossein Sanjari Moghaddam, Shahin Akhondzadeh   +3 more
doaj   +1 more source

Spironolactone effect on cardiac structure and function of patients with heart failure and preserved ejection fraction: a pooled analysis of three randomized trials

European Journal of Heart Failure, 2022
Spironolactone is currently used in a large proportion of patients with heart failure and preserved ejection fraction (HFpEF), yet its effect on cardiac structure and function in a large population has not been well established. The aim of this study was
J. Ferreira, J. Cleland, N. Girerd, E. Bozec, P. Rossignol, P. Pellicori, F. Cosmi, B. Mariottoni, S. Solomon, B. Pitt, M. Pfeffer, A. Shah, J. Petutschnigg, B. Pieske, F. Edelmann, F. Zannad   +15 more
semanticscholar   +1 more source

The potential of spironolactone to mitigate the risk of nonalcoholic fatty liver disease in hypertensive populations: evidence from a cohort study. [PDF]

Eur J Gastroenterol Hepatol
Shen D, Song S, Hu J, Cai X, Zhu Q, Zhang Y, Ma R, Zhou P, Zhang Z, Hong J, Li N.   +10 more
europepmc   +2 more sources

Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction

Circulation: Heart Failure, 2022
Background: The TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial) suggested clinical benefits of spironolactone treatment among patients with heart failure with preserved ejection fraction enrolled ...
A. Javaheri, A. Diab, Lei Zhao, Chenao Qian, Jordana B. Cohen, P. Zamani, Anupam Kumar, Zhaoqing Wang, Christina Ebert, Joseph C. Maranville, E. Kvikstad, M. Basso, V. V. van Empel, A. Richards, R. Doughty, E. Rietzschel, Karl Kammerhoff, J. Gogain, Peter H Schafer, D. Seiffert, D. Gordon, Francisco Ramírez-Valle, D. Mann, T. Cappola, J. Chirinos   +24 more
semanticscholar   +1 more source

A Randomized Trial of Combination Therapy, Sitagliptin and Spironolactone, in Hospitalized Adult Patients with COVID-19

Journal of the Endocrine Society, 2022
COVID-19 may cause respiratory distress syndrome and death. Treatment of COVID-19 to prevent complications remains a priority. Our investigation sought to determine whether combination of spironolactone and sitagliptin could reduce mortality for ...
F. Abbasi, R. Adatorwovor, M. Davarpanah, Y. Mansoori, Mehdi Hajiani, Farzan Azodi, S. Sefidbakht, Shayesteh Davoudi, Farzana Rezaei, S. Mohammadmoradi, K. Asadipooya   +10 more
semanticscholar   +1 more source

Association between Use of Spironolactone and Risk of Stroke in Hypertensive Patients: A Cohort Study

Pharmaceuticals, 2022
Objective: to investigate the relationship between the use of spironolactone and the risk of stroke in hypertensive patients. Methods: a total of 2464 spironolactone users and 12,928 non-users were identified (unmatched original cohort), and 1:1 matched ...
Xintian Cai, Nan-fang Li
semanticscholar   +1 more source

Retrospective analysis of adverse events with spironolactone in females reported to the United States Food and Drug Administration

International Journal of Women's Dermatology, 2020
Background: Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective: This study aimed to classify the most common adverse reactions associated with spironolactone in women of ...
Yu Wang, BA, Shari R. Lipner, MD, PhD
doaj   +1 more source