Results 31 to 40 of about 61,341 (287)

Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence

Biomedicines, 2022
We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients.
Laura E. J. Peeters, Leonardien K. Tjong, Wim J. R. Rietdijk, Teun van Gelder, Birgit C. P. Koch, Jorie Versmissen   +5 more
doaj   +1 more source

COVID-19—The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection

Pharmaceuticals, 2021
In March 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was declared a global pandemic by the World Health Organization (WHO). The clinical course of the disease is unpredictable but may lead to severe acute respiratory infection (SARI ...
K. Kotfis, Kacper Lechowicz, Sylwester Drożdżal, P. Niedźwiedzka-Rystwej, T. Wojdacz, E. Grywalska, J. Biernawska, M. Wiśniewska, M. Parczewski   +8 more
semanticscholar   +1 more source

Effects of Low-Dose Spironolactone Combined with Metformin or Either Drug Alone on Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Pilot Study

International Journal of Endocrinology, 2022
Metformin and spironolactone alone can be used for the management of polycystic ovarian syndrome (PCOS), and their combination could result in even better outcomes.
Tao Long, Ying Zhang, Chunping Zeng, Siyuan Zheng, Lin Zhou, Haiyan Liu   +5 more
doaj   +1 more source

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]

, 2017
Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A, Elliott, J, Hezzell, M J, Lopez-Alvarez, J, Lotter, N S   +4 more
core   +3 more sources

Association of spironolactone treatment and arterial stiffness and cardiovascular disease in hypertensive patients

Archives of Medical Science, 2019
Introduction The aim of the current study was to evaluate the association of spironolactone and arterial stiffness and composite cardiovascular disease (CVD, including coronary heart disease, congestive heart failure and ischemic stroke) in hypertensive ...
Fanfang Zeng, Rong Huang, Yongkang Lu, Zhiye Wu, Weiyi Mai, Lili Wang   +5 more
doaj   +1 more source

Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]

, 2020
Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D., Dickstein, Kenneth, Duarte, Kevin, Ferreira, Joao Pedro, Girerd, Nicolas, Kobayashi, Masatake, Lamiral, Zohra, Lang, Chim C., Metra, Macro, Ng, Leong L., Preud'homme, Gregoire, Rossignol, Patrick, Samani, Nilesh J., Stienen, Susan, ter Maaten, Jozine M., van Veldhuisen, Dirk J., Voors, Adriaan A., Zannad, Faiez   +17 more
core   +4 more sources

Exploration of sodium homeostasis and pharmacokinetics in bile duct-ligated rats treated by anti-cirrhosis herbal formula plus spironolactone

Frontiers in Pharmacology, 2023
Renal sodium retention is an essential indicator that is used for the prognosis of cirrhosis with ascites that requires diuretic treatment to restore sodium homeostasis.
Tun-Pin Hsueh, Tun-Pin Hsueh, Tun-Pin Hsueh, Tung-Hu Tsai, Tung-Hu Tsai, Tung-Hu Tsai   +5 more
doaj   +1 more source

Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver [PDF]

, 1987
Spironolactone and potassium canrenoate are diuretics that are used widely for management of cirrhotic ascites. The administration of spironolactone frequently leads to feminization, which has been noted less frequently with the use of potassium ...
Alfredo Di Leo, Antonio Francavilla, Armanini, Aten, Bannister, Bellati, Boisselle, Bradford, Burton, Chopra, Clark, Duffy, Dupont, Eagon, Eagon, Eagon, Eagon, Farrell, Francavilla, Francavilla, Francavilla, Francesco Guglielmi, Fromatin, Giuseppe Fanizza, Greenblatt, Gustafsson, Gustafsson, Huffman, Kneifel, Lorenzo Polimeno, Loriaux, Marco, Menard, Michele Barone, Niewoehner, Norstedt, Patricia K. Eagon, Porter, Porter, Powell-Jones, Rifka, Rogerson, Scatchard, Serafini, Thomas E. Starzl, Turocy, Van Thiel   +46 more
core   +1 more source

Biomarker‐based assessment of collagen cross‐linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling. Insights from the HOMAGE clinical trial

European Journal of Heart Failure, 2021
The HOMAGE randomized trial found that spironolactone reduced left atrial volume index (LAVI), E:A ratio, and a marker of collagen type I synthesis (procollagen type I C‐terminal propeptide) in patients at risk of heart failure (HF).
S. Ravassa, B. López, J. Ferreira, N. Girerd, E. Bozec, P. Pellicori, B. Mariottoni, F. Cosmi, M. Hazebroek, J. Verdonschot, J. Cuthbert, J. Petutschnigg, M. Moreno, S. Heymans, J. Staessen, B. Pieske, F. Edelmann, A. Clark, J. Cleland, F. Zannad, J. Díez, Arantxa González   +21 more
semanticscholar   +1 more source

Does aspirin detract from the benefits of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction? Probably! [PDF]

, 2017
No abstract ...
Aspirin Myocardial Infarction Study Research Group, Baigent, Baigent, Bonaca, Chin, Cleland, Cleland, Cleland, Cleland, Cleland, Cleland, Gelder, Homma, Lewis, Massie, Meune, Michel, Pitt, Pitt, Silva, Solomon, Tweeddale, Zannad, Zannad   +23 more
core   +1 more source