Results 31 to 40 of about 46,150 (319)

Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat. [PDF]

PLoS ONE, 2012
OBJECTIVE: Aldosterone, one of the main peptides in renin angiotensin aldosterone system (RAAS), has been suggested to mediate liver fibrosis and portal hypertension.
Wei Luo, Ying Meng, Hong-Li Ji, Chun-Qiu Pan, Shan Huang, Chang-Hui Yu, Li-Ming Xiao, Kai Cui, Shu-Yuan Ni, Zhen-Shu Zhang, Xu Li   +10 more
doaj   +1 more source

Causal Analysis of the TOPCAT Trial: Spironolactone for Preserved Cardiac Function Heart Failure [PDF]

NeurIPS 2022 Workshop on Causal Machine Learning for Real-World Impact (CML4Impact 2022), 2022
We describe the results of applying causal discovery methods on the data from a multi-site clinical trial, on the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT). The trial was inconclusive, with no clear benefits consistently shown for the whole cohort.
arxiv  

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

Does aspirin detract from the benefits of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction? Probably! [PDF]

, 2017
No abstract ...
Aspirin Myocardial Infarction Study Research Group, Baigent, Baigent, Bonaca, Chin, Cleland, Cleland, Cleland, Cleland, Cleland, Cleland, Gelder, Homma, Lewis, Massie, Meune, Michel, Pitt, Pitt, Silva, Solomon, Tweeddale, Zannad, Zannad   +23 more
core   +1 more source

Spironolactone-induced gynecomastia [PDF]

Canadian Medical Association Journal, 2007
What's your call? ![Figure][1] Figure. Bilateral breast tenderness and enlargement in a 76-year-old man with congestive heart failure. This patient reported bilateral increasing breast size and tenderness. Examination of his breasts revealed gynecomastia (Tanner stage III).
Alex Suter, Florim Cuculi, Paul Erne
openaire   +3 more sources

Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes.
Sudeep R. Aryal, Mohammed Siddiqui, Oleg F. Sharifov, Megan D. Coffin, Bin Zhang, Krishna K. Gaddam, Himanshu Gupta, Thomas S. Denney, Louis J. Dell'Italia, Suzanne Oparil, David A. Calhoun, Steven G. Lloyd   +11 more
doaj   +1 more source

Spironolactone use and risk of incident cancers:a retrospective, matched cohort study [PDF]

, 2016
AIMS: Spironolactone is widely used to treat heart failure, hypertension and liver disease with increased usage in recent years. Spironolactone has endocrine effects that could influence cancer risks and historical reports suggest possible links with ...
Armstrong, Biggar, Boston Collaborative Drug Surveillance Program, Danielson, Futterman, Gardiner, Herrett, Jick, Leung, Loube, Luthy, Mackenzie, McLaughlin, Mellemgaard, Ron, Selby, Shahar, Shapiro, Shaw, Stierer, Sundar, Terouanne, Thompson, Walley, Wei, Weinman, Yuan   +26 more
core   +3 more sources

Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study

Acta Dermato-Venereologica
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne.
Brigitte Dréno, Jean-Michel Nguyen, Ewa Hainaut, Laurent Machet, Marie-Thérèse Leccia, Nathalie Beneton, Jean-Paul Claudel, Philippe Célérier, Marie Le Moigne, Sarah Le Naour, Florence Vrignaud, Alexandra Poinas, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Simon Korner, Amir Khammari   +16 more
doaj   +1 more source

Hypertension - state of the art 2017 [PDF]

, 2017
No abstract ...
McCallum, Linsay
core   +1 more source

Effect of Spironolactone on Diabetic Nephropathy Compared to the Combination of Spironolactone and Losartan [PDF]

Nephro-Urology Monthly, 2014
Diabetic nephropathy is the most important cause of end stage renal disease (ESRD). Aldosterone is involved in renal damage through induction of fibrosis, inflammation and necrosis in the kidney tissue. Previous studies have demonstrated that the combination of angiotensin receptor blocker (ARB) and spironolactone (an anti-aldosterone drug) are ...
Zahra Kashi, Atieh Makhlough, Ozra Akha, Ehsan Zaboli, Jamshid Yazdani-Charati   +4 more
openaire   +3 more sources