Results 181 to 190 of about 3,654 (228)

An overview of spirooxindole as a promising scaffold for novel drug discovery

Expert Opinion on Drug Discovery, 2020
Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in some fields such as pharmaceutical chemistry and synthetic chemistry.
Li-Ming Zhou, Ren-Yu Qu, Guangfu Yang
semanticscholar   +1 more source

Synergistic applications of nanocomposite, ultrasound, and on‐water synthesis for efficient and green synthesis of spirooxindole derivatives via cascade C–N, C–O, and C–S bond formation

Applied organometallic chemistry
A highly efficient, green, and multicomponent reaction method has been developed for the diversity‐oriented synthesis of 32 spirooxindole derivatives via the formation of cascade C–N, C–O, and C–S bonds.
Pankaj Teli, Sunita Teli, Nusrat Sahiba, Shivani Soni, S. Agarwal   +4 more
semanticscholar   +1 more source

Organocatalytic Aza-Michael/Mannich Cascade Reaction: Synthesis of Enantioenriched 3,3'-Spirooxindole γ-Lactams.

Journal of Organic Chemistry, 2022
Highly enantioselective synthesis of 3,3'-spirooxindole γ-lactams with three contiguous stereocenters (two quaternary) was achieved. The aza-Michael/Mannich cascade reaction of α-imine-β-oxobutanamides and methyleneindolinones catalyzed by a bifunctional
Xiao-Tong Li, Heng-Zhi Tian, Xingwen Sun
semanticscholar   +1 more source

ChemInform Abstract: Spirooxindoles: Promising Scaffolds for Anticancer Agents

ChemInform, 2015
AbstractReview: 84 refs.
Bin Yu, Hong-Min Liu, De-Quan Yu
openaire   +4 more sources

Synthesis and anti-Cancer Activity of a New Hybrid Based Spirooxindole-Pyrrolidine -Thiochromene Scaffolds via [3 + 2] Cycloaddition Reaction: Computational Investigation

Polycyclic aromatic compounds (Print), 2022
A combined experimental and theoretical study of a newly synthesized cycloadduct of spirooxindole based thiochromene scaffold via [3 + 2] cycloaddition (32CA) reaction approach has been performed.
A. Barakat, M. Haukka, S. Soliman, A. M. Al‐Majid, M. Ali, M. Islam, A. Karami, Zaheer Ul-Haq, L. Domingo   +8 more
semanticscholar   +1 more source

Heteroatom-Controlled Three-Component [4 + 3] or [3 + 2] Annulation of Isatin-Derived Azomethine Ylide with Azadiene: Selective Synthesis of Spirooxindole-diazepines and Density Functional Theory Studies.

Organic Letters
A novel three-component [4 + 3] annulation reaction of isatin-derived azomethine ylides with azadienes was developed for the first time to efficiently synthesize spirooxindole-diazepines incorporating a benzothiophene moiety under catalyst-free ...
Jiali Huang, Aimin Yu, Lei Zhang, Xiangtai Meng   +3 more
semanticscholar   +1 more source

Catalytic asymmetric synthesis of spirooxindoles: recent developments

Chemical Communications, 2018
The past four years have witnessed significant developments in the field of the catalytic asymmetric synthesis of spirooxindoles, and this feature article outlines the recent progress in this area, including the contributions of our group. This article is divided into sections according to the size and type of the generated spiro-ring fused at the C3 ...
Guang-Jian Mei, Feng Shi
openaire   +3 more sources

Evaluation of Spirooxindole-3,3'-pyrrolines-incorporating Isoquinoline Motif as Antitumor, Anti-Inflammatory, Antibacterial, Antifungal, and Antioxidant Agents.

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
BACKGROUND A series of novel 2-(isoquinolin-1-yl)-spiro[oxindole-3,3'-pyrrolines] were synthesized by a one-pot three-component reaction involving dimethyl acetylenedicarboxylate, 3- phenylimidazo[5,1-a]isoquinoline and N-alkylisatins in chloroform at ...
Areej M. Jaber, Jalal A. Zahra, M. El‐Abadelah, Mohammed M. Al-Mahadeen, S. Sabri, V. Kasabri, Randa Haddadin   +6 more
semanticscholar   +1 more source

Spirooxindoles as Potential Pharmacophores

Mini-Reviews in Medicinal Chemistry, 2017
The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Rachel A. Jones, Siva S. Panda, Praveen Bachawala, Prabhu P. Mohapatra   +3 more
openaire   +3 more sources

Enantioselective Synthesis of Spirooxindole-pyran and furan Scaffolds via Copper-Catalyzed Formal (3+3) and (3+2) Cycloaddition of Isatin-derived Propargylic Esters.

Chemistry
Herein, we report a copper-catalyzed enantioselective formal (3+3) and (3+2) cycloaddition reaction of isatin-derived tertiary propargylic esters with N,N-dimethylbarbituric acid and 4-hydroxycoumarins, respectively.
Shweta Rohilla, Zahid Ahmad Khan, Vinod K Singh   +2 more
semanticscholar   +1 more source