Results 191 to 200 of about 3,654 (228)
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Angewandte Chemie, 2007
The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties.
C. Galliford, K. Scheidt
semanticscholar +1 more source
The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties.
C. Galliford, K. Scheidt
semanticscholar +1 more source
Advanced Synthesis & Catalysis
We describe a chiral phosphoric acid (CPA) catalyzed asymmetric [3+3] cycloaddition of N‐viny oxindole nitrones with 2‐indolylmethanols to prepare various spirooxindole[1,2]oxazines in 43‐93% yields and 88:12‐97:3 enantiomeric ratios.
Ning Zou +6 more
semanticscholar +1 more source
We describe a chiral phosphoric acid (CPA) catalyzed asymmetric [3+3] cycloaddition of N‐viny oxindole nitrones with 2‐indolylmethanols to prepare various spirooxindole[1,2]oxazines in 43‐93% yields and 88:12‐97:3 enantiomeric ratios.
Ning Zou +6 more
semanticscholar +1 more source
Molecular diversity of spirooxindoles. Synthesis and biological activity
Molecular Diversity, 2015Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Victoria V. Lipson +4 more
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Chemical Communications
We report an efficient, metal free method for synthesizing tetracyclic spirooxindole derivatives from N-protected isatins and propargyl bromide via Huisgen cycloaddition. This simple and practicle method provides access to spirooxindoles containing five-,
Sandip Maiti +3 more
semanticscholar +1 more source
We report an efficient, metal free method for synthesizing tetracyclic spirooxindole derivatives from N-protected isatins and propargyl bromide via Huisgen cycloaddition. This simple and practicle method provides access to spirooxindoles containing five-,
Sandip Maiti +3 more
semanticscholar +1 more source
Journal of Organic Chemistry, 2021
A highly diastereo- and enantioselective cyclopropanation reaction of 3-acylcoumarins with 3-halooxindoles catalyzed by an organocatalyst through a [2 + 1] Michael/intramolecular cyclization process was developed. This scenario provides a facile strategy
Weicheng Yuan +4 more
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A highly diastereo- and enantioselective cyclopropanation reaction of 3-acylcoumarins with 3-halooxindoles catalyzed by an organocatalyst through a [2 + 1] Michael/intramolecular cyclization process was developed. This scenario provides a facile strategy
Weicheng Yuan +4 more
semanticscholar +1 more source
Angewandte Chemie, 2021
A unified catalytic asymmetric (N + 1) (N = 4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst. This general strategy utilizes peroxides as unique bielectrophilic four-
Min Gao +6 more
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A unified catalytic asymmetric (N + 1) (N = 4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst. This general strategy utilizes peroxides as unique bielectrophilic four-
Min Gao +6 more
semanticscholar +1 more source
ChemInform Abstract: Titanium‐Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines.
ChemInform, 2010AbstractReaction of various isatins with 5‐methoxyoxazoles proceeds regioselectively and with high diastereoselectivity to afford spiro products (III) and (V).
James C. Fettinger +3 more
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Synthesis of Spirooxindoles via the tert-Amino Effect
Organic Letters, 2017A new method is developed for the synthesis of spirooxindoles from amines and isatins via C-H functionalization. The reaction leverages the tert-amino effect to form an enolate-iminium intermediate via [1,5]-hydride shift followed by cyclization. Interestingly the hydride migrates to the N atom of a C═N, which is atypical for hydride additions to ...
Kinthada Ramakumar +3 more
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Organocatalytic Approach to Spirooxindoles [PDF]
Synfacts, 2020 Paul Richardson, Victor Snieckus
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