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Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds
Topics in Current Chemistry, 2021Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in drug design processes. Significant attention has been directed at obtaining molecules based on spiroindole and spirooxindole derivatives that have bioactivity against cancer cells, microbes, and different types of disease affecting the human body.
Shima Nasri +2 more
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Organocatalytic Asymmetric Synthesis of Spirooxindole Embedded Oxazolidines
The Journal of Organic Chemistry, 2021The first organocatalytic asymmetric synthesis of spirooxindole embedded oxazolidines has been developed via a domino reaction involving hemiaminal formation, followed by an unprecedented aza-Michael reaction between isatin derived N-Boc ketimines and γ-hydroxy enones.
Chandrakanta Parida +3 more
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Molecular diversity of spirooxindoles. Synthesis and biological activity
Molecular Diversity, 2015Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Tetyana L, Pavlovska +3 more
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Titanium-Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines
Organic Letters, 2010A regio- and stereoselective cyclization between isatins and 5-methoxyoxazoles has been developed using catalytic titanium(IV) chloride (10 or 20 mol %) to afford spiro[3,3'-oxindoleoxazolines] in excellent yield (up to 99%) and diastereoselectivity (dr >99:1). Substitution at the 4-position of the oxazole controls nucleophilic attack to provide either
Joseph J, Badillo +3 more
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Superacid-Promoted synthesis of spirooxindoles
Tetrahedron Letters, 2023Jacob C. Hood +2 more
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Recent Advances in Nucleophilic Lewis Base‐Catalyzed Cycloadditions for Synthesis of Spirooxindoles
Advanced Synthesis and Catalysis, 2023Qingfeng Li, Erqing Li
exaly
Asymmetric Synthesis of Pharmacologically Active Spirooxindoles
Spirooxindoles are a class of organic compounds characterized by a spirocyclic framework, where an oxindole moiety (which is a structure containing an indole fused to a carbonyl group) is connected to another ring system via a spiro carbon atom. These compounds have attracted significant interest in medicinal chemistry due to their diverse biological ...Chanchal Vashisth +3 more
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