Results 51 to 60 of about 5,648 (138)
Molecular Genetics & Genomic Medicine, 2021 Objective PE is a pregnancy‐specific syndrome that affects 3%–5% of pregnant women. It often presents as new‐onset hypertension and proteinuria during the third trimester.
Tao Zhang +11 more
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The biological function and clinical significance of SF3B1 mutations in cancer
Biomarker Research, 2020 Spliceosome mutations have become the most interesting mutations detected in human cancer in recent years. The spliceosome, a large, dynamic multimegadalton small nuclear ribonucleoprotein composed of small nuclear RNAs associated with proteins, is ...
Zhixia Zhou +6 more
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Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA
eLife, 2013 Eukaryotes have two types of spliceosomes, comprised of either major (U1, U2, U4, U5, U6) or minor (U11, U12, U4atac, U6atac; <1%) snRNPs. The high conservation of minor introns, typically one amidst many major introns in several hundred genes ...
Ihab Younis +8 more
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Seminars in Cell & Developmental Biology, 2018 The U12-dependent (minor) spliceosome excises a rare group of introns that are characterized by a highly conserved 5' splice site and branch point sequence. Several new congenital or somatic diseases have recently been associated with mutations in components of the minor spliceosome.
Bhupendra, Verma +3 more
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Frontiers in Molecular Neuroscience, 2017 While the cytoplasmic function of microRNA (miRNA) as post-transcriptional regulators of mRNA has been the subject of significant research effort, their activity in the nucleus is less well characterized.
Belinda J. Goldie +11 more
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PLoS ONE, 2012 Human p29 is a putative component of spliceosomes, but its role in pre-mRNA is elusive. By siRNA knockdown and stable overexpression, we demonstrated that human p29 is involved in DNA damage response and Fanconi anemia pathway in cultured cells.
Chia-Hsin Chen +8 more
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YIPF2 regulates genome integrity
Cell & BioscienceUnderstanding of the mechanisms for genome integrity maintenance can help in developing effective intervention strategies to combat aging. A whole-genome RNAi screen was conducted to identify novel factors involved in maintaining genome stability.
Xiao Zhang, Tao Wang
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Grass ResearchPerennial ryegrass (Lolium perenne) is one of the most important cool-season grasses used for forage and turf purposes. Heat stress is the primary abiotic factor threatening its pasture/turf persistence.
Wenxi Zha +4 more
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