Results 51 to 60 of about 17,131 (322)
Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage [PDF]
, 2016 In response to DNA damage cells activate intricate protein networks to ensure genomic fidelity and tissue homeostasis. DNA damage response signaling pathways coordinate these networks and determine cellular fates, in part, by modulating RNA metabolism ...
Marteijn, J.A. (Jurgen) +2 more
core +2 more sources
Structure of spliceosomal ribonucleoproteins [PDF]
F1000 Biology Reports, 2010 Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates.
Kiyoshi Nagai +2 more
openaire +3 more sources
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
eLife, 2020 Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome.
Stefan Meinke +6 more
doaj +1 more source
Hepatology Communications, 2022 CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global abundance of circRNA and their involvement in hepatocellular carcinoma (HCC) development have not been ...
Lei He +11 more
doaj +1 more source
SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
doaj +1 more source
Pseudouridines in spliceosomal snRNAs [PDF]
Protein & Cell, 2011 Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T. Yu, Junhui Ge, Yi-Tao Yu
openaire +3 more sources
PLoS Genetics, 2015 Little is known about contacts in the spliceosome between proteins and intron nucleotides surrounding the pre-mRNA branch-site and their dynamics during splicing.
Cornelius Schneider +5 more
semanticscholar +1 more source
Zhongguo shuxue zazhi, 2022 Objective To analyze the polymorphisms of GYPA and GYPB mRNA spliceosomes associated with MNS blood group, and to explore the mechanism of subcellular localization of GPA and GPB protein isomerism encoded by various spliceosomes as well as the expression
Yanlian LIANG +5 more
doaj +1 more source
Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning [PDF]
, 2012 Brr2p is one of eight RNA helicases involved in pre-mRNA splicing. Detailed understanding of the functions of Brr2p and other spliceosomal helicases has been limited by lack of knowledge of their in vivo substrates. To address this, sites of direct Brr2p–
Beggs, Jean D +3 more
core +1 more source
Splicing diversity revealed by reduced spliceosomes in C. merolae and other organisms
RNA Biology, 2015 Pre-mRNA splicing has been considered one of the hallmarks of eukaryotes, yet its diversity is astonishing: the number of substrate introns for splicing ranges from hundreds of thousands in humans to a mere handful in certain parasites.
A. J. Hudson +4 more
semanticscholar +1 more source