Results 61 to 70 of about 17,120 (319)
Spliceosome Structure and Function [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and RNP networks, which serve to align the reactive groups of the pre-mRNA for catalysis, are formed and repeatedly rearranged during spliceosome assembly and catalysis.
Will, C., Lührmann, R.
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Zhongguo shuxue zazhi, 2022 Objective To analyze the polymorphisms of GYPA and GYPB mRNA spliceosomes associated with MNS blood group, and to explore the mechanism of subcellular localization of GPA and GPB protein isomerism encoded by various spliceosomes as well as the expression
Yanlian LIANG +5 more
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SnapShot: Spliceosome Dynamics I
Cell, 2015 Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome.
Wahl, M., Lührmann, R.
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Spliceosome Mutations in Uveal Melanoma [PDF]
International Journal of Molecular Sciences, 2020 Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential and mainly spreads to the liver. Genetics play a vital role in tumor classification and prognostication of UM metastatic disease. One of the driver genes mutated in metastasized UM is subunit 1 of splicing factor 3b (SF3B1), a component ...
Josephine Q.N. Nguyen +9 more
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U12 type introns were lost at multiple occasions during evolution
BMC Genomics, 2010 Background Two categories of introns are known, a common U2 type and a rare U12 type. These two types of introns are removed by distinct spliceosomes. The phylogenetic distribution of spliceosomal RNAs that are characteristic of the U12 spliceosome, i.e.
Bartschat Sebastian, Samuelsson Tore
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The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes*
Journal of Biological Chemistry, 2015 Background: Compounds that inhibit spliceosomes are of very limited availability. Results: A high-throughput screen of a marine bacteria natural products library identified a promising lead compound that inhibits pre-mRNA splicing in vitro. Conclusion: N-
Kerstin A. Effenberger +5 more
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Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes
RNA: A publication of the RNA Society, 2014 During logarithmic growth, Schizosaccharomyces pombe cells contain abundant, high-molecular-weight complexes harboring U2, U5, and U6 snRNAs. Chen et al.
Weijun Chen +8 more
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RNA: A publication of the RNA Society, 2014 The authors present the results of three independent mass spectrometry–based approaches to assess protein composition of precatalytic and catalytic spliceosomes.
Carla Schmidt +6 more
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Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes [PDF]
EMBO Journal, 2006 Britta M Rhode +3 more
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Identifying RNA splicing factors using IFT genes in Chlamydomonas reinhardtii [PDF]
, 2018 Intraflagellar transport moves proteins in and out of flagella/cilia and it is essential for the assembly of these organelles. Using whole-genome sequencing, we identified splice site mutations in two IFT genes,
Dutcher, Susan K. +3 more
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