Results 91 to 100 of about 737,931 (248)
The influenza A virus replicates in a broad range of avian and mammalian species by hijacking cellular factors and processes. Avian influenza A viruses (AIVs) generally propagated poorly in mammalian cells, but some mutants of virus-encoded RNA ...
Xingxing Ren+23 more
doaj +1 more source
Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals. [PDF]
ObjectiveThe NCoR-1 and NCoR-2 corepressors are products of an early gene duplication near the beginning of vertebrate evolution and play both overlapping and divergent roles in development and physiology.
Goodson, Michael L, Privalsky, Martin L
core
Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik+73 more
core +1 more source
Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer's disease [PDF]
Genetic variation in cis-regulatory elements related to splicing machinery and splicing regulatory elements (SREs) results in exon skipping and undesired protein products.
Alzheimer’s Disease Neuroimaging Initiative+8 more
core
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]
Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P.+11 more
core +3 more sources
MMSplice: modular modeling improves the predictions of genetic variant effects on splicing
Predicting the effects of genetic variants on splicing is highly relevant for human genetics. We describe the framework MMSplice (modular modeling of splicing) with which we built the winning model of the CAGI5 exon skipping prediction challenge.
Jun Cheng+6 more
semanticscholar +1 more source
Coordinated Alterations in RNA Splicing and Epigenetic Regulation Drive Leukemogenesis
Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of these processes are common in leukaemia1,2.
A. Yoshimi+28 more
semanticscholar +1 more source
Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies.
Carolyn M Jablonowski+20 more
doaj +1 more source
Aberrant RNA Splicing in Cancer.
RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression.
Luisa F. Escobar-Hoyos+2 more
semanticscholar +1 more source
Redox regulation of mammalian sperm capacitation
Capacitation is a series of morphological and metabolic changes necessary for the spermatozoon to achieve fertilizing ability. One of the earlier happenings during mammalian sperm capacitation is the production of reactive oxygen species (ROS) that will ...
Cristian O′Flaherty
doaj +1 more source