Results 191 to 200 of about 619,548 (333)

Additional file 1 of Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes

Sruthi Srinivasan, Sivaraman Subramanian, Hui Zhou, Anselm Hoppmann, Patrick Metzger, Melanie Boerries, Senthilkumar Ramamoorthy   +6 more
openalex   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Exploring Splicing-Energy Axis Associations to Diet and Longevity. [PDF]

Aging Cell
Donega S, Gorospe M, Ferrucci L.
europepmc   +1 more source

Urinary carbonic anhydrase IX splicing messenger RNA variants in urogenital cancers

, 2016
Francesca Malentacchi, Serena Vinci, Alessandro Della Melina, Jitka Kuncová, Donata Villari, Gabriella Nesi, Cesare Selli, Claudio Orlando, Mario Pazzagli, Pamela Pinzani   +9 more
openalex   +2 more sources

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

FIR/PUF60: Multifunctional Molecule Through RNA Splicing for Revealing the Novel Disease Mechanism and Effective Individualized Therapies. [PDF]

Int J Mol Sci
Matsushita K, Kitamura K, Tanaka N, Kobayashi S, Suenaga Y, Hoshino T.   +5 more
europepmc   +1 more source

Decision letter: SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

, 2020
Eric J. Wagner
openalex   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML. [PDF]

Cell Rep Med
Huang Y, Xiao P, Qin L, Gao L, Zhao Y, Sui J, Hu W, Zhou L, Han N, Lv X, Chen K, Liu Y, Lin H, Shen S, Abdel-Wahab O, Hu S, Liu Z, Wang Q.   +17 more
europepmc   +1 more source

SpliceAid-F: a database of human splicing factors and their RNA binding sites

, 2012
Matteo Giulietti, Francesco Piva, Mattia D’Antonio, Paolo D’Onorio De Meo, Tiziana Castrignanò, Giulio Pavesi, Graziano Pesole   +6 more
openalex   +2 more sources