Results 21 to 30 of about 325,490 (342)
Frontiers in Genetics, 2018 In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in
Alejandro Moles-Fernández +30 more
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European Journal of Combinatorics, 2011 We introduce and study a natural variant of matroid amalgams. For matroids M(A) and N(B) such that M/(A-B)=N(B-A), we define a splice of M and N to be a matroid L on the union of A and B with L(B-A)=M and L/(A-B)=N. We show that splices exist for each such pair of matroids M and N; furthermore, there is a freest splice of M and N, which we call the ...
Joseph E. Bonin, William Schmitt
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RNA Binding Proteins that Control Human Papillomavirus Gene Expression
Biomolecules, 2015 The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication ...
Naoko Kajitani, Stefan Schwartz
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Mutations primarily alter the inclusion of alternatively spliced exons
eLife, 2020 Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered splicing might be a common ...
Pablo Baeza-Centurion +3 more
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Splicing and alternative splicing in rice and humans
BMB Reports, 2013 Rice is a monocot gramineous crop, and one of the most important staple foods. Rice is considered a model species for most gramineous crops. Extensive research on rice has provided critical guidance for other crops, such as maize and wheat. In recent years, climate change and exacerbated soil degradation have resulted in a variety of abiotic stresses ...
Lei Wang, Jianhua Zhou, Zhiguo E
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Exon sequences at the splice junctions affect splicing fidelity and alternative splicing [PDF]
Proceedings of the National Academy of Sciences, 2009 Identification of splice sites is essential for the expression of most eukaryotic genes, allowing accurate splicing of pre-mRNAs. The splice sites are recognized by the splicing machinery based on sequences within the pre-mRNA. Here, we show that the exon sequences at the splice junctions play a significant, previously unrecognized role in the ...
Luciana B. Crotti, David S. Horowitz
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Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei [PDF]
, 2021 Trans-splicing of leader sequences onto the 59ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 59splice sites and analyze the corresponding gene expression profile, that we term spliced leader trapping (SLT).
arxiv +1 more source
Splice diagrams and splice-quotient surface singularities [PDF]
arXiv, 2022 The current work will appear in a Celebratio Mathematica volume in honor of Walter Neumann. We summarize results and methods from our long-time collaboration with Neumann, especially the motivation for the introduction of splice diagrams to define singularities of splice type and splice-quotient singularities. The Casson Invariant Conjecture and Milnor
arxiv
Alternative Splicing and Genomic Stability [PDF]
Physical Biology, volume 1, issue 2, pages C1 - C4, 2004, 2004 Alternative splicing allows an organism to make different proteins in different cells at different times, all from the same gene. In a cell that uses alternative splicing, the total length of all the exons is much shorter than in a cell that encodes the same set of proteins without alternative splicing.
arxiv +1 more source
Molecular Cell, 2007 A novel study in a recent issue of Molecular Cell (Shi and Manley, 2007) provides insight into a complex signaling pathway that controls the phosphorylation status of an SR-related protein that functions as a splicing repressor following heat shock-dependent dephosphorylation.
Guil, Sonia, Cáceres, Javier F.
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