Results 141 to 150 of about 215,491 (295)

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

Splicing factors tested for activity in SMN2 exon 7 splicing.

, 2014
Splicing factors tested for activity in SMN2 exon 7 splicing.
Mallory A. Havens (558474), Francine M. Jodelka (675291), Claribel D. Wee (675290), Michelle L. Hastings (31169)   +3 more
core   +1 more source

Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal‐to‐Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency

Advanced Science
During maternal‐to‐zygotic transition (MZT) in the embryo, mRNA undergoes complex post‐transcriptional regulatory processes. However, it is unclear whether and how alternative splicing plays a functional role in MZT. By analyzing transcriptome changes in
Hua Zhang, Yang Wang, Zhe‐Wei Hu, Yun‐Wen Wu, Nuo Chen, Yi‐Min Zhu, Yuan‐Song Yu, Heng‐Yu Fan, Hua‐Nan Wang   +8 more
doaj   +1 more source

FiN‐Kiri: Fabric‐Based Inflatable Kirigami Actuator for Multimodal Soft Robots

Advanced Robotics Research, EarlyView.
This study introduces a type of inflatable fabric‐based kirigami actuator capable of performing bending motion. The actuator is utilized as soft grippers, a crawling robot and a swimming robot. The crawling robot demonstrated extraordinary motion capabilities, such as moving forward, turning and navigating a narrow tunnel.
Yang Yu, Yupei Zhang, Yanqi Yin, Yehui Wu, Jinyao Zhang, Ruiyu Bai, Jiaqiang Yao, Kewei Su, Chenyi Yu, Zhicheng Tian, Naipeng Li, Zhuang Zhang, Bo Li   +12 more
wiley   +1 more source

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

FASEB BioAdvances
Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome. Acute endurance exercise appears to transiently perturb AS in skeletal muscle, but transcriptome‐wide responses are not ...
Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow   +5 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

, 2012
Most human genes produce multiple splicing isoforms with distinct functions. To systematically understand splicing regulation, we conducted an unbiased screen and identified>100 intronic splicing enhancers (ISEs) that were clustered by sequence ...
Wang, Yang, Meng Ma, Wang, Zefeng, Zefeng Wang, Xiao, Xinshu, Ma, Meng, Yang Wang, Xinshu Xiao   +7 more
core   +1 more source