Results 51 to 60 of about 120,027 (188)

Two-Factor Experiments with Split Units Constructed by Cyclic Designs and Square Lattice Designs

Revstat Statistical Journal, 2018
We consider nested row-column designs with split units for a two-factor experiment. The most optimal design in this case is that of using for the whole plots a Latin square while for the subplot treatments with a completely randomized design for each ...
Kazuhiro Ozawa , Iwona Mejza , Stanisław Mejza, Shinji Kuriki   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Response of lowland rice-ratooned rice-fluted pumpkin sequence to fertilizer in rainfed inland valley in derived savannah of Nigeria

Acta Agriculturae Slovenica, 2017
Trial was carried out at Federal University of Agriculture, Abeokuta, Nigeria between 2010 and 2012 to determine response of lowland rice-ratooned rice-fluted pumpkin sequence to fertilizer.
Sunday Ojo Adigbo, Joy N Odedina, Clement G Afolabi, Adebola A Osipitan, M Agbonlahor, T O Fabunmi, C O Adejuyigbe, F G Atanda, M L Nweke-Okoh   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Physiological and agronomic responses of maize (Zea maysL) cultivars to plant population and defoliation at post-anthesis in the humid rainforest

Acta Agriculturae Slovenica, 2018
Variations in response pattern of maize (Zea mays)grown at plant populations, defoliated at post-anthesis in the rainforest were tested. Two field trials were conducted at Abeokuta, (Longitude 3025’E, Latitude 7015’N; 144 m a.s.l) and Ibadan (3056’E ...
Olalekan Suleiman SAKARIYAWO, Doyin OGUNDIRAN, Paul SOREMI, Sunday ADERIBIGBE   +3 more
doaj   +1 more source

The use of pre-emergence herbicides in cassava decreases the need of manual weeding

Revista Ceres, 2020
Weed management consists of a fundamental practice in cassava, with mechanical and chemical control widely used. The objective of this work was to evaluate the efficacy of pre-emergence herbicides, as well as to determine the interaction of these with ...
Antonio Dias Santiago, Sergio de Oliveira Procópio, Guilherme Braga Pereira Braz, Camila Jorge Bernabé Ferreira   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source