Results 61 to 70 of about 3,491 (191)

Identification of orphan histidine kinases that impact sporulation and enterotoxin production by Clostridium perfringens type F strain SM101 in a pathophysiologically-relevant ex vivo mouse intestinal contents model.

open access: yesPLoS Pathogens, 2023
When causing food poisoning or antibiotic-associated diarrhea, Clostridium perfringens type F strains must sporulate to produce C. perfringens enterotoxin (CPE) in the intestines. C.
Iman Mehdizadeh Gohari   +5 more
doaj   +1 more source

The Bacillus subtilis SinR protein is a repressor of the key sporulation gene spo0A [PDF]

open access: yesJournal of Bacteriology, 1995
SinR is a pleiotropic DNA binding protein that is essential for the late-growth processes of competence and motility in Bacillus subtilis and is also a repressor of others, e.g., sporulation and subtilisin synthesis. In this report, we show that SinR, in addition to being an inhibitor of sporulation stage II gene expression, is a repressor of the key ...
I, Mandic-Mulec, L, Doukhan, I, Smith
openaire   +2 more sources

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

open access: yesMolecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang   +12 more
wiley   +1 more source

Molecular Insight into the Regulation of Cell Differentiation by a Master Regulator Spo0A in starving Bacillus subtilis cells

open access: yes, 2020
Gram-positive soil bacterium Bacillus subtilis can activate cellular differentiation pathways such as biofilm formation and sporulation, in response to starvation.
Marathe, Anuradha
core   +2 more sources

Inactivation Strategies of Clostridium perfringens in Foods: Current Challenges and Emerging Interventions

open access: yesFood Frontiers, Volume 7, Issue 3, May 2026.
Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi   +7 more
wiley   +1 more source

A toxin-mediated policing system in Bacillus optimizes division of labor via penalizing cheater-like nonproducers

open access: yeseLife, 2023
Division of labor, where subpopulations perform complementary tasks simultaneously within an assembly, characterizes major evolutionary transitions of cooperation in certain cases.
Rong Huang   +10 more
doaj   +1 more source

A Role for Asp75 in Domain Interactions in theBacillus subtilis Response Regulator Spo0A [PDF]

open access: yesJournal of Biological Chemistry, 2000
Spo0A is a two-domain response regulator required for sporulation initiation in Bacillus subtilis. Studies on response regulators have focused on the activity of each domain, but very little is known about the mechanism by which the regulatory domain inhibits the activator domain.
M A, Cervin, G B, Spiegelman
openaire   +2 more sources

A conserved switch controls virulence, sporulation, and motility in C. difficile.

open access: yesPLoS Pathogens
Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile. In all bacterial spore formers, sporulation is regulated through activation of the master response regulator, Spo0A.
Michael A DiCandia   +7 more
doaj   +1 more source

The RgaS-RgaR two-component system promotes Clostridioides difficile sporulation through a small RNA and the Agr1 system.

open access: yesPLoS Genetics, 2023
The ability to form a dormant spore is essential for the survival of the anaerobic pathogen, Clostridioides difficile, outside of the mammalian gastrointestinal tract.
Adrianne N Edwards, Shonna M McBride
doaj   +1 more source

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions

open access: yesEcology and Evolution, Volume 16, Issue 2, February 2026.
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Ehsan Pashay Ahi
wiley   +1 more source

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