Results 61 to 70 of about 74,782 (138)

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, EarlyView.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Targeting inflammatory pathways in axial spondyloarthritis. [PDF]

, 2019
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
core  

Efficacy and safety of brodalumab in palmoplantar pustulosis: A 68‐week randomized Phase 3 trial

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This open‐label study is a continuation of the 16‐week double‐blind, Phase 3 trial assessing the efficacy and safety of brodalumab 210 mg subcutaneously, till a 68‐week extension period. Continued improvement was seen in the PPPASI 50/75/90 responses, PPPSI scores, PGA 0/1 responses and DLQI. Abstract Background The efficacy and safety of brodalumab in
Masamoto Murakami, Yukari Okubo, Satomi Kobayashi, Natsuko Kikuta, Yoshiumi Ouchi, Kenta Shishido, Tadashi Terui   +6 more
wiley   +1 more source

Mid‐ to Long‐Term Follow‐Up Outcomes of Single Design Rotating Hinge Knee in Infected and Noninfected Revision Patients

Orthopaedic Surgery, EarlyView.
RHK prostheses are effective for revision TKA in cases of infection, instability, or loosening after primary TKA, with mid‐ to long‐term follow‐up showing good functional recovery and high implant survival. ABSTRACT Background Total knee arthroplasty (TKA) offers significant relief for advanced knee osteoarthritis.
Zhisen Gao, Tiejian Li, Ti Zhang, Minzhi Yang, Yonggang Zhou, Wei Chai   +5 more
wiley   +1 more source

Are Ankylosing Spondylitis Patients at Risk for Poor Total Hip Replacement Outcomes [PDF]

, 2017
Hip involvement in Ankylosing Spondylitis is common and leads to physical and function restriction. Hip replacement surgery is a successful and effective treatment for end-stage hip involvement; however in Ankylosing Spondylitis patient’s prosthesis ...
Alegre, C, Carvalho, M, Carvalho, P, Costa, C, Judas, F, Rodrigues, M   +5 more
core  

Clinical Characteristics and a New Classification System of Mono‐Segmental Thoracic and Lumbar Nonfusion in Patients With Ankylosing Spondylitis

Orthopaedic Surgery, EarlyView.
In regard to the mono‐segmental thoracic and lumbar nonfusion in patients with ankylosing spondylitis, we built a new classification system based on CT and MRI data and describe its clinical distribution characteristics and occurrence risk factors for the first time. ABSTRACT Study Design Retrospective cohort study.
Bingchuan Liu, Zhengguang Wang, Fang Zhou, Yun Tian, Zhishan Zhang   +4 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Self‐Assessment Triage for Inflammatory Arthritis: A Pilot Randomized Controlled Trial

ACR Open Rheumatology, Volume 8, Issue 2, February 2026.
Objective Prompt referral to a rheumatologist is essential for the prevention of joint damage in people with inflammatory arthritis (IA). We investigated whether rheumatology referrals can improve triage if additional information from two self‐assessment tools, namely the tender joint count (TJC) and the Early Inflammatory Arthritis Detection Tool ...
Raquel Sweezie, Charles H. Goldsmith, Xingshan Cao, Barry Koehler, Raheem B. Kherani, Sharron Sandhu, Alex Kiss, Mary J. Bell   +7 more
wiley   +1 more source

Retrospective analysis of cutaneous immune‐related adverse events following checkpoint inhibitor therapy in melanoma patients reveals increased risk associated with the HLA‐B*51:01 allele

Cancer, Volume 132, Issue 3, 1 February 2026.
ABSTRACT Background While immune checkpoint inhibitors (ICIs) have shown significant efficacy, a common side effect is cutaneous immune‐related adverse events (irAEs). This study focuses on exploring the association between specific human leukocyte antigen (HLA) alleles and the development of cutaneous irAEs in melanoma patients undergoing ICI ...
Mckenzie DiLeo, Samantha Oglesby, Cheuk Hong Leung, Kristen E. Pauken, Sahira Farooq, Lauren E. Haydu, Shelby L. Kubicki, Rebeca Martinez, Macartney Welborn, Sana Zahiruddin, Jun Zou, Kai Cao, Anisha B. Patel   +12 more
wiley   +1 more source

Development and Validation of the Brief Inventory of Treatment Expectations in Chronic Pain (BITEC)

European Journal of Pain, Volume 30, Issue 2, February 2026.
ABSTRACT Background Expectations shape therapeutic outcomes, yet their systematic assessment remains limited in clinical and research settings. To address this gap, we developed and validated the Brief Instrument for the Assessment of Treatment Expectations in Chronic Pain (BITEC) using Item Response Theory. Methods The study comprised four phases. (I)
Wolnei Caumo, Bárbara Regina França, Jaira Ehlers, Stela Maris de Jezus Castro, Rogério Boff Borges, Vania Naomi Hirakata, Graziele Borges Bueno, Iraci LS da Torres, Felipe Fregni   +8 more
wiley   +1 more source