Results 91 to 100 of about 7,170,848 (305)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2016 Xin Huang,1,2,* Fu-Qing Zhou,3,* Yu-Xiang Hu,1 Xiao-Xuan Xu,1 Xiong Zhou,4 Yu-Lin Zhong,1 Jun Wang,4 Xiao-Rong Wu1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First ...
Huang X +7 more
doaj
Frontiers in Neuroscience, 2019 Mechanical forces are increasingly recognized as major regulators of several physiological processes at both the molecular and cellular level; therefore, a deep understanding of the sensing of these forces and their conversion into electrical signals are
Marica Marrese +7 more
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Alteration of spontaneous brain activity in COPD patients
, 2016 Jiaxing Zhang,1 Ji Chen,1 Qian Yu,1 Cunxiu Fan,1 Ran Zhang,1 Jianzhong Lin,2 Tianhe Yang,2 Ming Fan3 1Department of Physiology, Medical College of Xiamen University, Xiangan, 2Magnetic Resonance Center, Department of Radiology, Zhongshan Hospital Xiamen
Zhang J +7 more
core
Sensory memory for odors is encoded in spontaneous correlated activity between olfactory glomeruli [PDF]
, 2006 Sensory memory is a short-lived persistence of a sensory stimulus in the nervous system, such as iconic memory in the visual system. However, little is known about the mechanisms underlying olfactory sensory memory.
Menzel, Randolf +5 more
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences
eLifeThe brain is thought to construct an optimal internal model representing the probabilistic structure of the environment accurately. Evidence suggests that spontaneous brain activity gives such a model by cycling through activity patterns evoked by ...
Toshitake Asabuki, Tomoki Fukai
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Motriz: Revista de Educacao Fisica, 2017 AIMS The aim of this study was to investigate the effects of short-term food restriction (6-weeks) on metabolic profile and spontaneous physical activity (SPA) of young male Wistar rats. METHODS Thirty rats had their baseline SPA measured at 21 days-old
Wladimir Rafael Beck +4 more
doaj +1 more source