Results 71 to 80 of about 1,331,499 (342)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Balancing the brain: resting state networks and deep brain stimulation

Frontiers in Integrative Neuroscience, 2011
Over the last three decades, large numbers of patients with otherwise treatment-resistant disorders have been helped by deep brain stimulation, yet a full scientific understanding of the underlying neural mechanisms is still missing.
Morten L Kringelbach, Morten L Kringelbach, Morten L Kringelbach, Alex L Green, Tipu Z Aziz, Tipu Z Aziz   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The effects of 3-nitropropionic acid on the behavior and cortical electrical activity of rats in acute administration [PDF]

, 2006
In this study, the acute effects of 3-nitropropionic acid was investigated on open field and startle behavior of rats, and on their cortical electrical activity.
Hebőkné Lukács, Anita, Papp, András, Szabó, Andrea, Vezér, Tünde   +3 more
core  

On the Dynamics of the Spontaneous Activity in Neuronal Networks

PLoS ONE, 2007
Most neuronal networks, even in the absence of external stimuli, produce spontaneous bursts of spikes separated by periods of reduced activity. The origin and functional role of these neuronal events are still unclear. The present work shows that the spontaneous activity of two very different networks, intact leech ganglia and dissociated cultures of ...
MAZZONI A, BROCCARD FD, GARCIA PEREZ E, BONIFAZI P, RUARO ME, Torre, Vincent   +5 more
openaire   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Monkey in the middle: Why nonhuman primates are needed to bridge the gap in resting-state investigations

Frontiers in Neuroanatomy, 2012
Resting-state investigations based on the evaluation of intrinsic low-frequency fluctuations of the BOLD fMRI signal have been extensively utilized to map the structure and dynamics of large-scale functional network organization in humans. In addition to
R. Matthew eHutchison, R. Matthew eHutchison, R. Matthew eHutchison, Stefan eEverling, Stefan eEverling, Stefan eEverling   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On the Origin of the 1,000 Hz Peak in the Spectrum of the Human Tympanic Electrical Noise

Frontiers in Neuroscience, 2017
The spectral analysis of the spontaneous activity recorded with an electrode positioned near the round window of the guinea pig cochlea shows a broad energy peak between 800 and 1,000 Hz. This spontaneous electric activity is called round window noise or
Javiera Pardo-Jadue, Constantino D. Dragicevic, Macarena Bowen, Macarena Bowen, Macarena Bowen, Paul H. Delano, Paul H. Delano   +6 more
doaj   +1 more source

Brain covariance selection: better individual functional connectivity models using population prior [PDF]

, 2010
Spontaneous brain activity, as observed in functional neuroimaging, has been shown to display reproducible structure that expresses brain architecture and carries markers of brain pathologies.
Gramfort, Alexandre, Poline, Jean Baptiste, Thirion, Bertrand, Varoquaux, Gaël   +3 more
core   +4 more sources