Results 71 to 80 of about 7,170,848 (305)

Modeling developmental patterns of spontaneous activity

, 2011
Spontaneous activity is found in many regions of the developing nervous system; such activity is thought to be instructive for guiding developmental processes.
Stephen J Eglen, Gjorgjieva, J., Julijana Gjorgjieva, Eglen, S.   +3 more
core   +1 more source

Brain regions showing spontaneous brain activity levels associated with SOC.

, 2023
Brain regions showing spontaneous brain activity levels associated with SOC.
Hidehiko Takahashi (291574), Shisei Tei (4371544), Junya Fujino (4371541), Kota Kanda (16475264)   +3 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABAA Receptor Activity

Frontiers in Cellular Neuroscience, 2018
GABAA receptors (GABAARs) play a crucial inhibitory role in the CNS. Benzodiazepines (BDZs) are positive modulators of specific subtypes of GABAARs, but the underlying mechanism remains obscure.
Magdalena Jatczak-Śliwa, Magdalena Jatczak-Śliwa, Katarzyna Terejko, Marek Brodzki, Marek Brodzki, Michał A. Michałowski, Michał A. Michałowski, Marta M. Czyzewska, Joanna M. Nowicka, Anna Andrzejczak, Rakenduvadhana Srinivasan, Jerzy W. Mozrzymas   +11 more
doaj   +1 more source

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

, 2010
As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with ...
Jiang, Tianzi, Song, Ming, T. Jiang, Song, Sonya W., Liu, Yong, Zhou, Yuan, Wang, Kun   +6 more
core  

Invited talk: The role of spontaneous activity in sensory processing [PDF]

, 2007
Spontaneous, background activity in sensory areas is often similar in both magnitude and form to evoked responses. Embedding responses evoked by sensory stimuli in such strong and complex background activity seems like a confusing way to represent ...
Abbott, Larry
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

A Plasminogen Activator in Spontaneously Active Human Blood.

Experimental Biology and Medicine, 1953
Summary1. Fibrinolytically active blood, as obtained from the living and dead human organism, contains a plasminogen activator. The amount of this activator exceeds many times that needed for the complete activation of the plasminogen present in human blood. 2.
openaire   +2 more sources