Changes in the EV-A71 Genome through Recombination and Spontaneous Mutations: Impact on Virulence [PDF]
Viruses, 2018 Enterovirus 71 (EV-A71) is a major etiological agent of hand, foot and mouth disease (HFMD) that mainly affects young children less than five years old. The onset of severe HFMD is due to neurological complications bringing about acute flaccid paralysis ...
Chit-Laa Poh
exaly +4 more sources
Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. [PDF]
BMC Biol, 2022 Background Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Crispr, and ...
Lewis MA +15 more
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Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii. [PDF]
PLoS Biol, 2019 Spontaneous mutations are the source of new genetic variation and are thus central to the evolutionary process. In molecular evolution and quantitative genetics, the nature of genetic variation depends critically on the distribution of effects of ...
Böndel KB +7 more
europepmc +2 more sources
Emergence of multidrug-resistant ST876 serotype 14 <i>Streptococcus pneumoniae</i> with spontaneous mutations driving pathogenesis: genomic and clinical insights from pneumococcal pericarditis and global screening. [PDF]
Front Cell Infect MicrobiolLiu L +12 more
europepmc +3 more sources
Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae. [PDF]
G3 (Bethesda), 2016 Estimates of the fitness effects of spontaneous mutations are important for understanding the adaptive potential of species. Here, we present the results of mutation accumulation experiments over 265–512 sequential generations in four species of marine ...
Krasovec M +6 more
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Spontaneous Mutations Occur More in Highly Transcribed Regions in Daphnia. [PDF]
Genome Biol EvolCoate JE, Ho EKH, Schaack S.
europepmc +2 more sources
Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases. [PDF]
Animal Model Exp MedCao Y, Tang H, Liang L, Leng J, Huang W.
europepmc +2 more sources
Cells, 2021 Mismatch Repair (MMR) is an important and conserved keeper of the maintenance of genetic information. Miroslav Radman’s contributions to the field of MMR are multiple and tremendous.
Marina Elez
doaj +1 more source
NIH4215: A mutation-prone thiamine auxotrophic clinical Aspergillus fumigatus isolate
Frontiers in Fungal Biology, 2022 Aspergillus fumigatus is the main cause of life-threatening invasive aspergillosis. Despite the availability of various antifungals, therapy remains challenging and requires further studies. Accordingly, the clinical A. fumigatus isolate NIH4215 deriving
Roberta Peres da Silva, Matthias Brock
doaj +1 more source
Spontaneous and induced mutations in the trees and shrubs of Serbia and their usability value [PDF]
Glasnik Šumarskog Fakulteta: Univerzitet u Beogradu, 2002 Mutations include the changes of the inherited material and they occur naturally, but very rarely. This paper presents the spontaneous and induced mutations, their frequency of occurrence and applicability for the needs of plant production in forestry ...
Tucović Aleksandar +2 more
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