Characterization of Plaque Variants and the Involvement of Quasi-Species in a Population of EV-A71
Viruses, 2020 Viral plaque morphologies in human cell lines are markers for growth capability and they have been used to assess the viral fitness and selection of attenuated mutants for live-attenuated vaccine development.
Madiiha Bibi Mandary +3 more
doaj +1 more source
Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli [PDF]
, 2011 The fidelity role of DNA polymerase I in chromosomal DNA replication in E. coli was investigated using the rpoB forward target. These experiments indicated that in a strain carrying a proofreading-exonuclease-defective form of Pol I (polAexo mutant) the ...
Jonczyk, Piotr +7 more
core +2 more sources
Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions
Vaccines, 2023 EV-A71 is a common viral pathogen that causes hand, foot and mouth disease. It is a single-stranded RNA virus that has a low fidelity RNA polymerase and, as a result, spontaneous mutations frequently occur in the EV-A71 genome.
Jia Xuen Koh +4 more
doaj +1 more source
On aging and age-specific effects of spontaneous mutations
, 2023 Evolutionary theory assumes that mutations that cause aging either have beneficial early-life effects that gradually become deleterious with advancing age (antagonistic pleiotropy [AP]) or that they only have deleterious effects at old age (mutation ...
Brengdahl, Martin, I +27 more
core +1 more source
PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION [PDF]
Evolution, 1999 Mildly deleterious mutation has been invoked as a leading explanation for a diverse array of observations in evolutionary genetics and molecular evolution and is thought to be a significant risk of extinction for small populations. However, much of the empirical evidence for the deleterious-mutation process derives from studies of Drosophila ...
Lynch, M. +6 more
openaire +4 more sources
Microbiology Spectrum, 2023 The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB.
Jin Shi +10 more
doaj +1 more source
Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK. [PDF]
Microb Cell, 2018 Chronologically aging yeast cells are prone to adaptive regrowth, whereby mutants with a survival advantage spontaneously appear and re-enter the cell cycle in stationary phase cultures. Adaptive regrowth is especially noticeable with short-lived strains,
Maqani N +5 more
europepmc +2 more sources
Genome-Wide Estimation of the Spontaneous Mutation Rate of Human Adenovirus 5 by High-Fidelity Deep Sequencing. [PDF]
PLoS Pathogens, 2016 Rates of spontaneous mutation determine the ability of viruses to evolve, infect new hosts, evade immunity and undergo drug resistance. Contrarily to RNA viruses, few mutation rate estimates have been obtained for DNA viruses, because their high ...
Jennifer Risso-Ballester +2 more
doaj +1 more source
Avaliação de clones de banana Cavendish Evaluation of cavendish banana clones
Ciência e Agrotecnologia, 2006 Na bananeira ocorrem variações somaclonais em taxa muito superior ao que se observa na maioria das outras culturas, provavelmente em função da instabilidade mitótica. Objetivou-se com o presente trabalho avaliar clones de bananeira Cavendish coletados em
Sebastião de Oliveira e Silva +4 more
doaj +1 more source
LSL-KrasG12D; LSL-Trp53R172H/+; Ink4flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer. [PDF]
PLoS ONE, 2017 Pancreatic cancer (PC) accumulates multiple genetic mutations, including activating KRAS mutations and inactivating TP53, SMAD4 and CDKN2A mutations, during progression.
Lixiang Ma, Hexige Saiyin
doaj +1 more source