Results 21 to 30 of about 1,239,617 (330)

A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability. [PDF]

PLoS Genetics, 2013
Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of chromatin on mutagenesis is poorly understood.
Lyudmila Y Kadyrova, Tony M Mertz, Yu Zhang, Matthew R Northam, Ziwei Sheng, Kirill S Lobachev, Polina V Shcherbakova, Farid A Kadyrov   +7 more
doaj   +1 more source

Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain

eLife, 2022
SNAREs are undoubtedly one of the core elements of synaptic transmission. Contrary to the well characterized function of their SNARE domains bringing the plasma and vesicular membranes together, the level of contribution of their juxtamembrane domain ...
Gülçin Vardar, Andrea Salazar-Lázaro, Sina Zobel, Thorsten Trimbuch, Christian Rosenmund   +4 more
doaj   +1 more source

Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii [PDF]

, 2014
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rate at which new genetic variation for fitness is created by mutation, are important for the understanding of many biological processes. However, the causes
Ness, Rob W, Keightley, Peter D, Colegrave, N, Morgan, Andrew D   +3 more
core   +1 more source

Temperature dependence of spontaneous mutation rates [PDF]

Genome Research, 2020
Mutation is the source of genetic variation and the fundament of evolution. Temperature has long been suggested to have a direct impact on realized spontaneous mutation rates. If mutation rates vary in response to environmental conditions, such as the variation of the ambient temperature through space and time, they should no longer be described as ...
Ann-Marie Waldvogel, Markus Pfenninger
openaire   +3 more sources

Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination

mSphere, 2017
Emerging fungal diseases of wildlife are on the rise worldwide, and the white-nose syndrome (WNS) epidemic in North American bats is a catastrophic example. The causal agent of WNS is a single clone of the fungus Pseudogymnoascus destructans.
Jigar Trivedi, Josianne Lachapelle, Karen J. Vanderwolf, Vikram Misra, Craig K. R. Willis, John M. Ratcliffe, Rob W. Ness, James B. Anderson, Linda M. Kohn   +8 more
doaj   +1 more source

Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its fractions against UV-induced mutations in bacterial and yeast cells [PDF]

Archives of Biological Sciences, 2005
The inhibition of spontaneous and UV-induced mutations by essential oil (EO) of sage (Salvia officinalis L.) and its fractions F1-F5 containing different proportions of mono- and sesquiterpenes was studied with the Salmonella/microsome, E.
Knežević-Vukčević Jelena B., Vuković-Gačić Branka S., Stević Tatjana, Stanojević Jasna, Nikolić Biljana, Simić Draga   +5 more
doaj   +1 more source

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? [PDF]

, 2005
Introduction: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA.
O'Sullivan, DM, O'Sullivan, D M, McHugh, TD, Timothy D. McHugh, O'Sullivan, Denise M, Gillespie, S H, Gillespie, Stephen H, Gillespie, SH, Stephen H. Gillespie, McHugh, Timothy D, Denise M. O'Sullivan, McHugh, T D   +11 more
core   +1 more source

Secondary Metabolism and Interspecific Competition Affect Accumulation of Spontaneous Mutants in the GacS-GacA Regulatory System in Pseudomonas protegens

mBio, 2018
Secondary metabolites are synthesized by many microorganisms and provide a fitness benefit in the presence of competitors and predators. Secondary metabolism also can be costly, as it shunts energy and intermediates from primary metabolism.
Qing Yan, Lucas D. Lopes, Brenda T. Shaffer, Teresa A. Kidarsa, Oliver Vining, Benjamin Philmus, Chunxu Song, Virginia O. Stockwell, Jos M. Raaijmakers, Kerry L. McPhail, Fernando D. Andreote, Jeff H. Chang, Joyce E. Loper   +12 more
doaj   +1 more source

Rates of Spontaneous Mutation

Genetics, 1998
Abstract Rates of spontaneous mutation per genome as measured in the laboratory are remarkably similar within broad groups of organisms but differ strikingly among groups. Mutation rates in RNA viruses, whose genomes contain ca. 104 bases, are roughly 1 per genome per replication for lytic viruses and roughly 0.1 per genome per ...
J W, Drake, B, Charlesworth, D, Charlesworth, J F, Crow   +3 more
openaire   +2 more sources

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source