Results 91 to 100 of about 16,859 (216)

Application of quantitative DTI metrics in sporadic CJD

NeuroImage: Clinical, 2014
Diffusion Weighted Imaging is extremely important for the diagnosis of probable sporadic Jakob–Creutzfeldt disease, the most common human prion disease.
E. Caverzasi, R.G. Henry, P. Vitali, I.V. Lobach, J. Kornak, S. Bastianello, S.J. DeArmond, B.L. Miller, H.J. Rosen, M.L. Mandelli, M.D. Geschwind   +10 more
doaj   +1 more source

Fatal familial insomnia that begins with unconsciousness: A case report

Sleep Research, Volume 3, Issue 1, Page 71-77, March 2026.
Wenyan Liu, Xinyue Xing, Xiaoming Wang, Xuqian Liu, Mingyue Liu, Wei Shang, Zhaohong Xie   +6 more
wiley   +1 more source

Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The amyloid cascade hypothesis places amyloid‐β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregation and a later phase that progresses at least partly independently of Aβ.
Natalie Beschorner, Ying Xu, Mathias Jucker, Alejandro Ruiz‐Riquelme   +3 more
wiley   +1 more source

Inflammatory Cerebrospinal Fluid in Sporadic Creutzfeldt-Jakob Disease [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2008
Background:Sporadic Creutzfeldt-Jakob disease (CJD) is a fatal, transmissible spongiform encephalopathy characterized by rapidly progressive dementia, myoclonus, ataxia and akinetic mutism. The underlying mechanism is believed to be a conformational change of a native prion protein which characteristically fails to provoke an immune response ...
Esther, Bui, Eric, Ehrensperger, Demetrios J, Sahlas, Brian J, Murray, Catherine, Bergeron, Rafael S, Glikstein, Richard, Aviv, Hyman M, Schipper   +7 more
openaire   +2 more sources

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer, Lea T. Grinberg, Jared T. Ahrendsen, Thomas G. Beach, Kevin F. Bieniek, Rudolph J. Castellani, Rati Chkheidze, Inma Cobos, Mark Cohen, John F. Crary, Dennis W. Dickson, Brittany N. Dugger, Sara R. Dunlop, Kurt Farrell, Bernardino Ghetti, Mohammad Haeri, William Harrison, Elizabeth Head, Annie Hiniker, Eric J. Huang, Anita Huttner, Pouya Jamshidi, Alifiya Kapasi, C. Dirk Keene, Julia Kofler, Caitlin S. Latimer, Ann C. McKee, Karin Mente, Michael B. Miller, Thomas J. Montine, Meaghan Morris, Melissa E. Murray, Peter T. Nelson, Kathy L. Newell, Richard J. Perrin, Biswarathan Ramani, R. Ross Reichard, Subhojit Roy, Johannes C. M. Schlachetzki, William W. Seeley, Geidy E. Serrano, Salvatore Spina, Andrew F. Teich, Shih‐Hsiu J. Wang, Thomas Wisniewski, Edward B. Lee   +45 more
wiley   +1 more source

Sporadic Creutzfeldt–Jakob Disease Appears to Be Sporadic Fatal Insomnia: A Case Report and Review of the Literature

Nature and Science of Sleep, 2021
Qingqing Sun, Pingping Shen, Jiayi Tang, Hongmei Meng, Jiachun Feng, Zan Wang, Li Cui Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Zan Wang; Li Cui ...
Sun Q, Shen P, Tang J, Meng H, Feng J, Wang Z, Cui L   +6 more
doaj  

Sporadic Creutzfeldt-Jakob Disease

Türk Nöroloji Dergisi, 2013
Abstract Not ...
Degirmenci, E., Degirmenci, T., Erdogan, Ç., Aras, D., Kiroglu, Y., Oguzhanoglu, A.   +5 more
openaire   +2 more sources

Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease.

Journal of clinical neuroscience, 2019
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease. It is invariably fatal and displays a short clinical disease stage.
Eirini Kanata, E. Golańska, Anna Villar-Piqué, Aikaterini Karsanidou, D. Dafou, Konstantinos Xanthopoulos, M. Schmitz, I. Ferrer, A. Karch, B. Sikorska, P. Liberski, T. Sklaviadis, I. Zerr, F. Llorens   +13 more
semanticscholar   +1 more source

Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases

BioEssays, Volume 47, Issue 9, September 2025.
The energy landscape of Aβ reveals its flexible, “chameleon‐like” behavior, enabling diverse structures from disordered to β‐rich forms. This polymorphism facilitates aggregation, contributing to Alzheimer's disease progression, while the flat landscape also allows disaggregation, potentially slowing disease progression compared to prion proteins with ...
Birgit Strodel
wiley   +1 more source

Transmission of CJD from nasal brushings but not spinal fluid or RT‐QuIC product

Annals of Clinical and Translational Neurology, 2020
Objective The detection of prion seeding activity in CSF and olfactory mucosal brushings using real‐time quaking‐induced conversion assays allows highly accurate clinical diagnosis of sporadic Creutzfeldt–Jakob disease.
Gregory J. Raymond, Brent Race, Christina D. Orrú, Lynne D. Raymond, Matilde Bongianni, Michele Fiorini, Bradley R. Groveman, Sergio Ferrari, Luca Sacchetto, Andrew G. Hughson, Salvatore Monaco, Maurizio Pocchiari, Gianluigi Zanusso, Byron Caughey   +13 more
doaj   +1 more source