Results 71 to 80 of about 16,281 (217)

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Transgenic Plasmodium berghei sporozoites expressing β-galactosidase for quantification of sporozoite transmission [PDF]

Molecular and Biochemical Parasitology, 2006
Malaria transmission occurs during a blood-meal of an infected Anopheles mosquito. Visualization and quantification of sporozoites along the journey from the mosquito midgut, where they develop, to the vertebrate liver, their final target organ, is important for understanding many aspects of sporozoite biology.
Sabine, Engelmann, Photini, Sinnis, Kai, Matuschewski   +2 more
openaire   +2 more sources

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

eLife
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso.
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema   +16 more
doaj   +1 more source

Plasmodium sporozoite motility: an update

Frontiers in Bioscience, 2012
Plasmodium, the causative agent of malaria, employs its own actin/myosin-based motor for forward locomotion, penetration of molecular and cellular barriers, and invasion of target cells. The sporozoite is unique amongst the extracellular Plasmodium developmental forms in that it has to cross considerable distances and different tissues inside the ...
Montagna, Georgina Nuri, Matuschewski, Kai, Buscaglia, Carlos Andres   +2 more
openaire   +5 more sources

Vaccination With Sporozoites: Models and Correlates of Protection [PDF]

Frontiers in Immunology, 2019
Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity.
Yun Shan Goh, Daniel McGuire, Daniel McGuire, Laurent Rénia, Laurent Rénia, Laurent Rénia   +5 more
openaire   +5 more sources

A pairwise comparison of sporoblast against sporozoite and schizont stages.

, 2018
2845 genes differentially expressed in sporozoite and schizont stages in comparison to sporoblast, plus 647 and 310 only differentially expressed relative to the sporozoite or the schizont stages, respectively.
Steven G. Nyanjom (3841954), Esther Kanduma (3485213), Pilar Corredor-Moreno (5843342), Moses N. Njahira (222424), Triza Tonui (5843339), Joyce Njuguna (3179466), Roger Pelle (59739), Appolinaire Djikeng (41915), Joana C. Silva (81113)   +8 more
core   +1 more source

Evidence of blood stage efficacy with a virosomal malaria vaccine in a Phase IIa clinical trial [PDF]

, 2008
Background Previous research indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine.
Gerd Pluschke, Sarah C. Gilbert, Hill, Adrian, Hutchings, Claire, Gilbert Sarah C., Sinden, Robert, Gilbert, Sarah C., Zurbriggen Rinaldo, Vogel, Denise, Jack L. Williams, Andrews Laura, Westerfeld Nicole, Andrews, Laura, David W. Porter, Thompson, Fiona, Okitsu, Shinji, Ian Poulton, Shinji L. Okitsu, Denise Vogel, Dunachie Susanna, Thompson Fiona M., Berthoud, Tamara, Porter David W., Pluschke, Gerd, Sarah C Gilbert, Sinden Robert, Poulton Ian, Fiona M Thompson, Zurbriggen, Rinaldo, Rinaldo Zurbriggen, Susanna Dunachie, Westerfeld, Nicole, Tamara Berthoud, Todryk, Stephen, Okitsu Shinji L., Hill Adrian V. S., Correa Simon, Berthoud Tamara, David W Porter, Nicole Westerfeld, Todryk Stephen, Porter, David, Correa, Simon, Pluschke Gerd, Poulton, Ian, Hutchings Claire, Vogel Denise, Shinji L Okitsu, Fiona M. Thompson, Jack L Williams, Simon Correa, Laura Andrews, Dunachie, Susanna, Adrian V S Hill, Robert Sinden, Stephen Todryk, Williams, Jack, Claire Hutchings, Williams Jack L., Thompson, Fiona M., Williams, Jack L., Porter, David W., Okitsu, Shinji L., Hill, Adrian V. S.   +63 more
core   +1 more source

ELISA and sporozoite gliding inhibition data

, 2018
This file contains individual-level data on antibody titers against circumsporozoite protein (CSP), Liver stage antigen-1 (LSA-1) and asexual parasite lysate as well as functional data on sporozoite gliding ...
Behet, Marije, Bousema, Teun, Grignard, Lynn, Alfred B. Tiono (8138718), Nébié, Issa, Soulama, Issiaka, Issa Nébié (3285813), Dechering, Koen J., Robert Sauerwein (74733), Chris Drakeley (79962), Alphonse Ouedraogo (4575280), Ouedraogo, Alphonse, Drakeley, Chris, Aissata Barry (6034850), Lynn Grignard (3555296), Judith M. Bolscher (8138712), Marije Behet (4435150), Kjerstin Lanke (264378), Gonçalves, Bronner P., Bronner P. Gonçalves (8138721), Koen J. Dechering (8138715), Teun Bousema (79969), Barry, Aissata, Issiaka Soulama (209863), Tiono, Alfred B., Sauerwein, Robert, Lanke, Kjerstin, Bolscher, Judith M.   +27 more
core   +2 more sources

Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine

Frontiers in Cellular and Infection Microbiology, 2017
Continuous stage conversion and swift changes in the antigenic repertoire in response to acquired immunity are hallmarks of complex eukaryotic pathogens, including Plasmodium species, the causative agents of malaria.
Oriana Kreutzfeld, Katja Müller, Kai Matuschewski   +2 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source