Results 101 to 110 of about 14,501 (156)

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Cell Reports, 2017
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacking ...
Annie S.P. Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody C. Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey   +14 more
doaj   +1 more source

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source

An Improved Theileria parva Sporozoite Seroneutralization Assay for the Identification of East Coast Fever Immune Correlates

Antibodies
Background: Immune correlates of protection are ideal tools to predict treatment or vaccine efficacy. However, the accuracy of the immune correlate and the capability to robustly predict the outcome of a vaccine candidate are determined by the ...
Hannah Chege, Samuel Githigia, James Gathumbi, Naomi Chege, Rose Ojuok, Josiah Odaba, Stephen Mwalimu, Harriet Oboge, Lucilla Steinaa, Vishvanath Nene, Anna Lacasta   +10 more
doaj   +1 more source

Detecting malaria sporozoites in live, field-collected mosquitoes [PDF]

, 2017
A method is described for identifying malaria-infected mosquitoes, without killing them or hampering their fitness. Individual mosquitoes were induced to salivate on coverslips, and sporozoites, deposited on the glass surface, were visualized by Giemsa ...
Betschart, B., Esposito, F., Habluetzel, A., Jenni, L., Merzagora, L., Rotigliano, G.   +5 more
core   +1 more source

Outdoor Mosquito Control Using Odour-Baited Devices: Development and Evaluation of a Potential New Strategy to Complement Indoor Malaria Prevention Methods [PDF]

, 2013
A considerable effort is currently underway to develop a malaria vaccine based on live Plasmodium falciparum sporozoites. The first requisite of a sporozoite vaccine is the guarantee of parasite arrest prior to the onset of the pathogenic blood stage ...
Kaindoa, Emmanuel W., Lwetoijera, Dickson W., Madumla, Edith P., Matowo, Nancy S., Moshi, Irene R., Mwangungulu, Stephen P., Okumu, Fredros O., Sumaye, Robert D.   +7 more
core  

Overcoming health systems barriers to successful malaria treatment.

, 2013
The success of malaria control programmes is recognised to be handicapped by the capacity of the health system to deliver interventions such as first-line treatment at optimal coverage and quality.
Ghani, Azra C, Rao, V Bhargavi, Schellenberg, David   +2 more
core   +1 more source

Detection of cryptosporidium oocysts in water and environmental concentrates [PDF]

, 1997
Whilst current methods for the isolation and enumeration of Cryptosporidium spp. oocysts in water have provided some insight into their occurrence and significance, they are regarded as being inefficient, variable and time-consuming, with much of the ...
Smith, H.V.
core  

Is vaccination the only option for possible global malaria eradication? [PDF]

, 2006
In the last century, vaccines, together with the discovery of antibiotics have been powerful tools in the management of infectious diseases. Both were of particular importance in reducing the morbidity and mortality associated with infections prevailing ...
Tonna, Ivan
core  

Transmission indices of malaria in Anopheles mosquitoes in an agrarian community adjourning Osogbo, Southwestern Nigeria

Journal of Vector Borne Diseases
Background & objectives: Mosquitoes transmit malaria and other infectious diseases. A thorough understanding of the dynamics, biting behavior, and infectiousness of Anopheles vector sporozoites is required to calculate transmission indices and develop ...
Zarat O Iwalewa, Olabanji A Surakat, Mohammed A Rufai, Kamilu A Fasasi, Harun K Aremu, Monsuru A Adeleke   +5 more
doaj   +1 more source

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

eLife
It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso.
Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema   +16 more
doaj   +1 more source