Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis [PDF]
, 2005 In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus.
Borght, Karin van der, +4 more
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Acute oral toxicity of zein nanoparticles with encapsulated gamma oryzanol in Sprague Dawley rats [PDF]
E3S Web of Conferences, 2021 Gamma oryzanol (GO) is well known for its antioxidant activity and health-promoting benefits. The gamma oryzanol-loaded zein nanoparticles (GOZNs) were successfully prepared in our previous study. In the present work, the acute oral toxicity of GOZNs was
Rodsuwan Ubonphan +6 more
doaj +1 more source
Keishibukuryogan is not carcinogenic in Sprague-Dawley rats
Journal of Toxicologic Pathology, 2016 Keishibukuryogan is a traditional Japanese medicine widely administered to patients with menopausal symptoms. Because humans use it on a long-term basis, we believed that a carcinogenicity study was warranted. We orally administered keishibukuryogan (TJ-25) extract powder to 6-week-old Sprague-Dawley rats [Crl:CD(SD)], which were divided into four ...
Masanao Kanitani +3 more
openaire +4 more sources
Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders. [PDF]
, 2016 The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social ...
Bauman, Melissa D +4 more
core +3 more sources
Ovarian Neoplasia in the Sprague-Dawley Rat [PDF]
Environmental Health Perspectives, 1987 Macroscopic and microscopic characteristics of 210 spontaneous ovarian tumors from 7748 Sprague-Dawley rats are described. The tumors were classified as tubular adenoma, anaplastic adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, mesothelioma, sertoliform tubular adenoma, Sertoli's cell tumor, granulosa cell tumor, thecal cell tumor,
openaire +3 more sources
Use Of The Prebiotic Inulin In The Prevention Of Adverse Signs Of Acute Colitis
Acta Veterinaria, 2015 The aim of this study was to investigate the influence of prebiotic inulin diet intervention on the activity of β-glucuronidase and counts of coliforms and lactobacilli in fresh caecal digesta, cytokine levels (IL-6, IL-8) and transcription nuclear ...
Emília Hijová +5 more
doaj +1 more source
Reproductive and developmental effects of phthalate diesters in females. [PDF]
, 2013 Phthalate diesters, widely used in flexible plastics and consumer products, have become prevalent contaminants in the environment. Human exposure is ubiquitous and higher phthalate metabolite concentrations documented in patients using medications with ...
Chambers, Christina +2 more
core +1 more source
Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles [PDF]
Scientific Reports 7, Article number: 2822 (2017), 2017 Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome. Conflicting studies have been reported on whether AgNPs result in gut dysbiosis and other changes within the host. We
arxiv +1 more source
Mathematical methods and models for radiation carcinogenesis studies [PDF]
, 1986 Research on radiation carcinogenesis requires a twofold approach. Studies of primary molecular lesions and subsequent cytogenetic changes are essential, but they cannot at present provide numerical estimates of the risk of small doses of ionizing ...
A.M. Kellerer +25 more
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The neuroprotective effect of Sulindac after ischemia-reperfusion injury in rats [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To investigate the neuroprotective effects of Sulindac on the hippocampal complex after global cerebral ischemia/reperfusion (I/R) injury in rats.METHODS: Thirty one Sprague-Dawley rats were used, distributed into group I (sham) n:7 were used as
Murat Cosar +10 more
doaj +1 more source