Results 81 to 90 of about 67,757 (265)
Behaviors of a micro oil droplet in an EHL contact
Friction, 2016 Oil–air lubrication supplies lubricants in the form of droplets to elastohydrodynamic lubrication (EHL) contacts, such as those in high-speed spindle bearings.
Xinming Li +4 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Distinct Spreading Speeds in a Lotka–Volterra Cooperative System
Journal of Mathematics, 2020 This paper deals with the spreading speeds in the classical Lotka–Volterra cooperative system, of which the bounds have been studied earlier. By introducing an auxiliary cooperative system and constructing an upper solution, we obtain a sufficient condition to confirm two distinct spreading speeds of unknown functions.
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Results in PhysicsThe enhanced spreading of a 2D drop on a stiff and free-standing elastic thin film theoretically investigated by Shanahan (Rev. Phys. Appl. 1988, 23, 1031–1037) has not been studied and verified experimentally. To shed a light on this interesting problem,
Yanbo Yao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Spatial dynamics of a nonlocal dispersal vector disease model with spatio-temporal delay
Electronic Journal of Differential Equations, 2015 This article concerns the spatial dynamics of a nonlocal dispersal vector disease model with spatio-temporal delay. We establish the existence of spreading speeds and construct some new types of solutions which are different from the traveling wave ...
Jia-Bing Wang +2 more
doaj
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A discrete time model for epidemic spread: traveling waves and spreading speeds
Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics, 2017 In this paper, we aim to study spread of an epidemic in a spatiallystratifed population with non-overlapping generations. We consider mean field equation of an endemic chain-binomial process and allow individuals to disperse in the spatial habitat. To be able to model the spatial movement, we used an averaging kernel.
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