Results 81 to 90 of about 479,813 (291)
Zika: The Formidable Speed of Viral Spread [PDF]
Berkeley Scientific Journal, 2016 ZIKA: THE FORMIDABLE SPEED OF VIRAL SPREAD BY MICHELLE VERGHESE I n 1947, deep inside the Zika Forest of Uganda, a group of scientists studying yellow fever happened upon something unexpected. A Rhesus monkey they were studying had developed a fever. However, the disease ultimately isolated from the monkey’s serum was certainly not yellow fever: it was
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2015 The current paper is concerned with the existence of spreading speeds and linear determinacy for two species competition systems with nonlocal dispersal in time and space periodic habitats.
W. Shen, L. Kong, N. Rawal
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Spatial dynamics of a nonlocal dispersal vector disease model with spatio-temporal delay
Electronic Journal of Differential Equations, 2015 This article concerns the spatial dynamics of a nonlocal dispersal vector disease model with spatio-temporal delay. We establish the existence of spreading speeds and construct some new types of solutions which are different from the traveling wave ...
Jia-Bing Wang +2 more
doaj
AgronomyTo address practical issues, such as uneven fertilizer distribution and poor particle dispersion, during the operation of a centrifugal double-disc fertilizer spreader, a discrete element method (DEM) simulation was initially performed.
Mingxiong Ou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The role of convection on spreading speeds and linear determinacy for reaction-diffusion-convection systems. [PDF]
, 2015 This thesis is concerned with spreading speeds and linear determinacy for both discretetime recursion models Un+1 = Q[un] and reaction-diffusion-convection systems (PDE) under a co-operative assumption.
Ameera Nema Al-Kiffai
core
Spreading speeds and traveling waves for periodic evolution systems [PDF]
, 2006 The theory of spreading speeds and traveling waves for monotone autonomous semiflows is extended to periodic semiflows in the monostable case. Then these abstract results are applied to a periodic system modeling man–environment–man epidemics, a periodic
Liang, Xing +2 more
core +1 more source