Results 61 to 70 of about 353,966 (351)

Sputum Galactomannan Has Utility in the Diagnosis of Chronic Pulmonary Aspergillosis

Journal of Fungi, 2022
Diagnosis of pulmonary aspergillosis (PA), a fungal disease caused by Aspergillus species, is challenging since symptoms are unspecific. The galactomannan (antigen secreted by Aspergillus species) test in bronchoalveolar lavage (BAL) fluid is a valuable ...
Ali Nuh, Newara Ramadan, Anand Shah, Darius Armstrong-James   +3 more
doaj   +1 more source

Home-based tuberculosis contact investigation in Uganda: a household randomised trial. [PDF]

, 2019
IntroductionThe World Health Organization (WHO) recommends household tuberculosis (TB) contact investigation in low-income countries, but most contacts do not complete a full clinical and laboratory evaluation.MethodsWe performed a randomised trial of ...
Armstrong-Hough, Mari, Ayakaka, Irene, Babirye, Diana, Cattamanchi, Adithya, Davis, J Lucian, Dowdy, David, Fair, Elizabeth, Ggita, Joseph, Haberer, Jessica E, Katamba, Achilles, Mark, David, Meyer, Amanda J, Mugabe, Frank, Ochom, Emma, Okello, Daniel Ayen, Turimumahoro, Patricia, Vittinghoff, Eric   +16 more
core   +1 more source

Challenges and Opportunities to Improve Tuberculosis Screening Among Immigrant Plantation Workers in Sabah, Malaysia [PDF]

, 2016
Tuberculosis (TB) among immigrants has substantial contribution to the TB epidemiology in Sabah. This study aimed to determine the yield of screening for TB disease among immigrant plantation workers in Sabah, Malaysia.
Abdullah, M. R. (Mohamed), Mohammad, W. M. (Wan), Omar, J. (Julia), Sabait, M. (Maini)   +3 more
core   +2 more sources

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Bacteria in the airways of patients with cystic fibrosis are genetically capable of producing VOCs in breath. [PDF]

, 2016
Breath contains hundreds of volatile organic compounds (VOCs), the composition of which is altered in a wide variety of diseases. Bacteria are implicated in the formation of VOCs, but the biochemical mechanisms that lead to the formation of breath VOCs ...
Blake, Donald, Bos, Lieuwe DJ, Meinardi, Simone, Whiteson, Katrine   +3 more
core   +2 more sources

Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients

PLoS ONE, 2017
Background Bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. However, the evidence base for antibiotic therapy is limited.
M. Cox, E. Turek, C. Hennessy, Ghazala K Mirza, P. James, M. Coleman, A. Jones, Robert S. Wilson, D. Bilton, W. Cookson, M. Moffatt, M. Loebinger   +11 more
semanticscholar   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Microbial Landscape and Antibiotic-Susceptibility Profiles of Microorganisms in Patients with Bacterial Pneumonia: A Comparative Cross-Sectional Study of COVID-19 and Non-COVID-19 Cases in Aktobe, Kazakhstan

Antibiotics, 2023
This cross-sectional study investigated the microbial landscape and antibiotic-resistance patterns in patients with bacterial pneumonia, with a focus on the impact of COVID-19.
Nurgul Ablakimova, Aigul Z. Mussina, Gaziza A. Smagulova, Svetlana Rachina, Meirambek S. Kurmangazin, Aigerim Balapasheva, Dinara Karimoldayeva, Afshin Zare, Mahdi Mahdipour, Farhad Rahmanifar   +9 more
doaj   +1 more source

Tuberculosis in Malta : a case for sputum induction [PDF]

, 2013
Sputum induction is a procedure used to help patients expectorate samples of sputum for laboratory analysis. It is a simple, safe and standardised procedure which may avoid the use of more invasive and potentially harmful interventions such as fibreoptic
Farrugia, Brian
core  

Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum

Clinical Cancer Research, 2016
Purpose: CT screening can reduce death from lung cancer. We sought to improve the diagnostic accuracy of lung cancer screening using ultrasensitive methods and a lung cancer–specific gene panel to detect DNA methylation in sputum and plasma. Experimental
A. Hulbert, I. Jusué-Torres, A. Stark, Chen Chen, Kristen Rodgers, Beverly Lee, Candace Griffin, A. Yang, Peng Huang, J. Wrangle, S. Belinsky, Tza-Huei Wang, Stephen C. Yang, S. Baylin, M. Brock, J. Herman   +15 more
semanticscholar   +1 more source